Thyroid nodules over 4 cm do not have higher malignancy or benign cytology false-negative rates

Muhammed Kizilgul, Rupendra Shrestha, Angela Radulescu, Maria R. Evasovich, Lynn A. Burmeister

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Purpose: Whether thyroid nodules 4 cm or larger with benign cytology carry a higher risk of malignancy, and should be managed differently than smaller nodules remains controversial. We aimed to evaluate the malignancy rate and benign cytology false-negative rate in thyroid nodules ≥4 cm compared with those <4 cm. Methods: All thyroidectomies between January 2010 and December 2014 were reviewed. Patient demographics, preoperative sonographic nodule size, fine needle aspiration cytology (FNAC), and final surgical pathology results were compared for index nodules ≥4 vs. <4 cm. Results: A total of 490 index nodules with preoperative FNAC were identified. A total of 137 nodules were ≥4 cm and 353 nodules were <4 cm. The prevalence of carcinoma was lower (23 vs. 53%) in nodules ≥4 vs. <4 cm (p < 0.0001). The false-negative rate of benign FNAC for ≥4 and <4 cm index nodule was 5.2% and 5.9%, respectively (p = 1.000). Conclusions: This study shows that thyroid nodules ≥4 cm do not have a higher malignancy rate at surgery nor higher benign cytology false-negative rate than smaller nodules. Thyroid nodules over 4 cm do not require resection, to rule out malignancy, based on size alone.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalEndocrine
Volume66
Issue number2
DOIs
StatePublished - Nov 1 2019

Bibliographical note

Funding Information:
This study was funded by the National Institutes of Health?s National Center for Advancing Translational Sciences, grant UL1TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health?s National Center for Advancing Translational Sciences. Muhammed Kizilgul was supported by a grant from The Scientific and Technical Research Council of Turkey (TUBITAK).

Funding Information:
Funding This study was funded by the National Institutes of Health’s National Center for Advancing Translational Sciences, grant UL1TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health’s National Center for Advancing Translational Sciences. Muhammed Kizilgul was supported by a grant from The Scientific and Technical Research Council of Turkey (TUBITAK).

Keywords

  • False-negative rate
  • Size
  • Thyroid carcinoma
  • Thyroid nodule
  • ≥4 cm

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