Thyroxine administration during radiation therapy to the neck does not prevent subsequent thyroid dysfunction

John P. Bantle, Chung K.K. Lee, Seymour H. Levitt

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

In an attempt to reduce the incidence of hypothyroidism following irradiation of the neck, we administered oral L-thyroxine in doses sufficient to suppress serum TSH to 20 patients receiving radiation therapy for Hodgkin's disease or other lymphomas. L-thyroxine was discontinued when radiation therapy was completed. Twenty similar patients who did not receive L-thyroxine during radiation therapy served as a control group. After a mean follow-up period of 33 months, seven patients (35%) in the L-thyroxine group developed elevation of serum TSH and were started on chronic L-thyroxine therapy. In the control group, after mean follow-up of 19 months, five patients (25%) developed elevation of TSH and were started on chronic L-thyroxine. We conclude that suppression of serum TSH during neck irradiation does not prevent subsequent thyroid dysfunction.

Original languageEnglish (US)
Pages (from-to)1999-2002
Number of pages4
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume11
Issue number11
DOIs
StatePublished - Nov 1985

Bibliographical note

Funding Information:
Supported by Clinical Research Center Grant RR400 from the Division of Research Resources, National Institutes of Health.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Hypothyroidism
  • L-thyroxine
  • Radiation therapy
  • TSH suppression

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