Abstract
The inter- or intramolecular oxidative carboamination of alkynes catalyzed by [py2TiCl2NPh]2 is reported. These multicomponent reactions couple alkenes, alkynes and diazenes to form either α,β-unsaturated imines or α-(iminomethyl)cyclopropanes via a TiII/TiIV redox cycle. Each of these products is formed from a common azatitanacyclohexene intermediate that undergoes either β-H elimination or α,γ-coupling, wherein the selectivity is under substrate control.
Original language | English (US) |
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Pages (from-to) | 14570-14573 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 138 |
Issue number | 44 |
DOIs | |
State | Published - Nov 9 2016 |
Bibliographical note
Funding Information:Financial support was provided by the University of Minnesota (start-up funds) and the National Institutes of Health (1R35GM119457). Equipment for the Chemistry Department NMR facility were supported through a grant from the National Institutes of Health (S10OD011952) with matching funds from the University of Minnesota.
Publisher Copyright:
© 2016 American Chemical Society.