TY - JOUR
T1 - Time Course of Thymoxamine Reversal of Phenylephrine-Induced Mydriasis
AU - Wright, Martha M.
AU - Skuta, Gregory L.
AU - Drake, Michael V.
AU - Chang, Lisa F.
AU - Rabbani, Roya
AU - Musch, David C.
AU - Teikari, Jaakko
PY - 1990/12
Y1 - 1990/12
N2 - We conducted a randomized, double-masked, paired comparison of 0.1% thymoxamine vs placebo for the reversal of phenylephrine-induced mydriasis. Mydriasis was induced with 2.5% phenylephrine in each eye of 74 subjects (148 eyes). Each subject then received 0.1% thymoxamine in one eye and placebo in the other eye. Pupillary measurements were obtained at regular intervals during the ensuing 8 hours. At all intervals, a greater percentage of thymoxamine-treated eyes returned to baseline pupillary diameters compared with placebo-treated eyes (P≤.01). For subjects in whom both pupils returned to baseline, thymoxamine-treated eyes returned to baseline in a mean of 2.2 hours, vs 5.2 hours for placebo (P<.0001). Among thymoxamine-treated eyes, those with light irides responded more rapidly than those with dark irides, returning to baseline in 1.6 vs 2.8 hours, respectively (P =.0046). After constriction to baseline pupillary diameter had been achieved, no patients experienced a rebound dilation.
AB - We conducted a randomized, double-masked, paired comparison of 0.1% thymoxamine vs placebo for the reversal of phenylephrine-induced mydriasis. Mydriasis was induced with 2.5% phenylephrine in each eye of 74 subjects (148 eyes). Each subject then received 0.1% thymoxamine in one eye and placebo in the other eye. Pupillary measurements were obtained at regular intervals during the ensuing 8 hours. At all intervals, a greater percentage of thymoxamine-treated eyes returned to baseline pupillary diameters compared with placebo-treated eyes (P≤.01). For subjects in whom both pupils returned to baseline, thymoxamine-treated eyes returned to baseline in a mean of 2.2 hours, vs 5.2 hours for placebo (P<.0001). Among thymoxamine-treated eyes, those with light irides responded more rapidly than those with dark irides, returning to baseline in 1.6 vs 2.8 hours, respectively (P =.0046). After constriction to baseline pupillary diameter had been achieved, no patients experienced a rebound dilation.
UR - http://www.scopus.com/inward/record.url?scp=0025675526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025675526&partnerID=8YFLogxK
U2 - 10.1001/archopht.1990.01070140083034
DO - 10.1001/archopht.1990.01070140083034
M3 - Article
C2 - 2147844
AN - SCOPUS:0025675526
SN - 0003-9950
VL - 108
SP - 1729
EP - 1732
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 12
ER -