Time-restricted eating for 12 weeks does not adversely alter bone turnover in overweight adults

Andrea J. Lobene; Satchidananda Panda; Douglas G. Mashek; Emily N.C. Manoogian; Kathleen M. Hill Gallant; Lisa S. Chow

doi:10.3390/nu13041155

Time-restricted eating for 12 weeks does not adversely alter bone turnover in overweight adults

Andrea J. Lobene, Satchidananda Panda, Douglas G. Mashek, Emily N.C. Manoogian, Kathleen M. Hill Gallant, Lisa S. Chow

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Abstract

Weight loss is a major focus of research and public health efforts. Time-restricted eating (TRE) is shown to be effective for weight loss, but the impact on bone is unclear. Short-term TRE studies show no effect on bone mineral density (BMD), but no study has measured bone turnover markers. This secondary analysis examined the effect of 12 weeks of TRE vs. unrestricted eating on bone turnover and BMD. Overweight and obese adults aged 18–65 y (n = 20) were randomized to TRE (ad libitum 8-h eating window) or non-TRE. Serum N-terminal propeptide of type I collagen (P1NP), cross-linked N-telopeptide of type I collagen (NTX), and parathyroid hormone (PTH) levels were measured and dual-energy X-ray absorptiometry (DXA) scans were taken pre-and post-intervention. In both groups, P1NP decreased significantly (p = 0.04) but trended to a greater decrease in the non-TRE group (p = 0.07). The treatment time interaction for bone mineral content (BMC) was significant (p = 0.02), such that BMC increased in the TRE group and decreased in the non-TRE group. Change in P1NP was inversely correlated with change in weight (p = 0.04) overall, but not within each group. These findings suggest that TRE does not adversely affect bone over a moderate timeframe. Further research should examine the long-term effects of TRE on bone.

Original language	English (US)
Article number	1155
Journal	Nutrients
Volume	13
Issue number	4
DOIs	https://doi.org/10.3390/nu13041155
State	Published - Apr 2021

Bibliographical note

Funding Information:
Funding: This research was funded by the National Institutes of Health (K.M.H.G.: K01DK102864), (L.S.C.: R01DK124484), (S.P.: R01DK118278) and the Indiana Clinical and Translational Sciences Institute (A.J.L.), which is supported by two awards from the National Institutes of Health (UL1TR002529 and TL1TR002531). This work was also supported by the Healthy Foods Healthy Lives program (17SFR-2YR50LC to L.S.C.) and the National Institutes of Health (NIH National Center for Advancing Translational Sciences, UL1TR002494). The Larry L Hillblom Foundation funded a fellowship for E.N.C.M.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Bone health
Bone turnover markers
Humans
Time-restricted eating

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title = "Time-restricted eating for 12 weeks does not adversely alter bone turnover in overweight adults",

abstract = "Weight loss is a major focus of research and public health efforts. Time-restricted eating (TRE) is shown to be effective for weight loss, but the impact on bone is unclear. Short-term TRE studies show no effect on bone mineral density (BMD), but no study has measured bone turnover markers. This secondary analysis examined the effect of 12 weeks of TRE vs. unrestricted eating on bone turnover and BMD. Overweight and obese adults aged 18–65 y (n = 20) were randomized to TRE (ad libitum 8-h eating window) or non-TRE. Serum N-terminal propeptide of type I collagen (P1NP), cross-linked N-telopeptide of type I collagen (NTX), and parathyroid hormone (PTH) levels were measured and dual-energy X-ray absorptiometry (DXA) scans were taken pre-and post-intervention. In both groups, P1NP decreased significantly (p = 0.04) but trended to a greater decrease in the non-TRE group (p = 0.07). The treatment time interaction for bone mineral content (BMC) was significant (p = 0.02), such that BMC increased in the TRE group and decreased in the non-TRE group. Change in P1NP was inversely correlated with change in weight (p = 0.04) overall, but not within each group. These findings suggest that TRE does not adversely affect bone over a moderate timeframe. Further research should examine the long-term effects of TRE on bone.",

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note = "Funding Information: Funding: This research was funded by the National Institutes of Health (K.M.H.G.: K01DK102864), (L.S.C.: R01DK124484), (S.P.: R01DK118278) and the Indiana Clinical and Translational Sciences Institute (A.J.L.), which is supported by two awards from the National Institutes of Health (UL1TR002529 and TL1TR002531). This work was also supported by the Healthy Foods Healthy Lives program (17SFR-2YR50LC to L.S.C.) and the National Institutes of Health (NIH National Center for Advancing Translational Sciences, UL1TR002494). The Larry L Hillblom Foundation funded a fellowship for E.N.C.M. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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N2 - Weight loss is a major focus of research and public health efforts. Time-restricted eating (TRE) is shown to be effective for weight loss, but the impact on bone is unclear. Short-term TRE studies show no effect on bone mineral density (BMD), but no study has measured bone turnover markers. This secondary analysis examined the effect of 12 weeks of TRE vs. unrestricted eating on bone turnover and BMD. Overweight and obese adults aged 18–65 y (n = 20) were randomized to TRE (ad libitum 8-h eating window) or non-TRE. Serum N-terminal propeptide of type I collagen (P1NP), cross-linked N-telopeptide of type I collagen (NTX), and parathyroid hormone (PTH) levels were measured and dual-energy X-ray absorptiometry (DXA) scans were taken pre-and post-intervention. In both groups, P1NP decreased significantly (p = 0.04) but trended to a greater decrease in the non-TRE group (p = 0.07). The treatment time interaction for bone mineral content (BMC) was significant (p = 0.02), such that BMC increased in the TRE group and decreased in the non-TRE group. Change in P1NP was inversely correlated with change in weight (p = 0.04) overall, but not within each group. These findings suggest that TRE does not adversely affect bone over a moderate timeframe. Further research should examine the long-term effects of TRE on bone.

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Time-restricted eating for 12 weeks does not adversely alter bone turnover in overweight adults

Abstract

Bibliographical note

Keywords

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