Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral blood, they have not yet been well characterized, but are transcriptionally, phenotypically, and functionally distinct from recirculating central and effector memory Tcells. In this review, we will summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and will highlight technical considerations for studying this population. Tissue-resident memory T (Trm) cells are a recently defined Tcell subset that does not recirculate and accelerates local pathogen clearance. Schenkel and Masopust summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and highlight technical considerations for studying this cell population.
Bibliographical noteFunding Information:
This work was supported by National Institutes of Health grants R01AI084913 and R01AI111671 (to D.M.)
© 2014 Elsevier Inc.