Tissue specific differences in rate limiting factors of glutamate metabolism in enzyme systems of kidney and liver

Ernest Kun; Horace H. Loh; Pierre Volfin

doi:10.1016/0006-291X(66)90457-8

Tissue specific differences in rate limiting factors of glutamate metabolism in enzyme systems of kidney and liver

Ernest Kun, Horace H. Loh, Pierre Volfin

Pharmacology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In kidney tissue, the quantity of glutamate dehydrogenase limits metabolic flux of glutamate in accordance with predicted linear kinetic coupling of the dehydrogenase with transaminases (cf. 2). In liver tissue, however, control mechanisms of the glutamate system are not related in an obvious manner to the quantity of enzymes for which glutamate is a common substrate.

Original language	English (US)
Pages (from-to)	702-706
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/0006-291X(66)90457-8
State	Published - Jun 13 1966

Bibliographical note

Funding Information:
supported by research grants of the USPHS, and of the NSF, GB-3488. We are indebted to for the availability of ref. 9 prior to its appearance 6. Kun, E. and Volfin, P.: 7. Kun, E. and Achmatowicz, 8. Hermann, G. and Kun, 9. Chance, B., Jamieson, state of reduced pyridine conditions. If 3rd Internat.

Access

10.1016/0006-291X(66)90457-8

OpenUrl availability

Full text

Cite this

@article{2b0da8be613840d1bcbee38414559ca9,

title = "Tissue specific differences in rate limiting factors of glutamate metabolism in enzyme systems of kidney and liver",

abstract = "In kidney tissue, the quantity of glutamate dehydrogenase limits metabolic flux of glutamate in accordance with predicted linear kinetic coupling of the dehydrogenase with transaminases (cf. 2). In liver tissue, however, control mechanisms of the glutamate system are not related in an obvious manner to the quantity of enzymes for which glutamate is a common substrate.",

author = "Ernest Kun and Loh, {Horace H.} and Pierre Volfin",

note = "Funding Information: supported by research grants of the USPHS, and of the NSF, GB-3488. We are indebted to for the availability of ref. 9 prior to its appearance 6. Kun, E. and Volfin, P.: 7. Kun, E. and Achmatowicz, 8. Hermann, G. and Kun, 9. Chance, B., Jamieson, state of reduced pyridine conditions. If 3rd Internat.",

year = "1966",

month = jun,

day = "13",

doi = "10.1016/0006-291X(66)90457-8",

language = "English (US)",

volume = "23",

pages = "702--706",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "5",

}

TY - JOUR

T1 - Tissue specific differences in rate limiting factors of glutamate metabolism in enzyme systems of kidney and liver

AU - Kun, Ernest

AU - Loh, Horace H.

AU - Volfin, Pierre

N1 - Funding Information: supported by research grants of the USPHS, and of the NSF, GB-3488. We are indebted to for the availability of ref. 9 prior to its appearance 6. Kun, E. and Volfin, P.: 7. Kun, E. and Achmatowicz, 8. Hermann, G. and Kun, 9. Chance, B., Jamieson, state of reduced pyridine conditions. If 3rd Internat.

PY - 1966/6/13

Y1 - 1966/6/13

N2 - In kidney tissue, the quantity of glutamate dehydrogenase limits metabolic flux of glutamate in accordance with predicted linear kinetic coupling of the dehydrogenase with transaminases (cf. 2). In liver tissue, however, control mechanisms of the glutamate system are not related in an obvious manner to the quantity of enzymes for which glutamate is a common substrate.

AB - In kidney tissue, the quantity of glutamate dehydrogenase limits metabolic flux of glutamate in accordance with predicted linear kinetic coupling of the dehydrogenase with transaminases (cf. 2). In liver tissue, however, control mechanisms of the glutamate system are not related in an obvious manner to the quantity of enzymes for which glutamate is a common substrate.

UR - http://www.scopus.com/inward/record.url?scp=0014013669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014013669&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(66)90457-8

DO - 10.1016/0006-291X(66)90457-8

M3 - Article

C2 - 4381469

AN - SCOPUS:0014013669

SN - 0006-291X

VL - 23

SP - 702

EP - 706

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 5

ER -

Tissue specific differences in rate limiting factors of glutamate metabolism in enzyme systems of kidney and liver

Abstract

Bibliographical note

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this