Tobacco carcinogen research to aid understanding of cancer risk and influence policy

Hitesh Singhavi, Jasjit S. Ahluwalia, Irina Stepanov, Prakash C. Gupta, Vikram Gota, Pankaj Chaturvedi, Samir S. Khariwala

Research output: Contribution to journalReview articlepeer-review

Abstract

Education regarding the health effects associated with tobacco use has made important progress worldwide over the last few decades. Still, tobacco remains a significant cause of cancer and other diseases. As a result, significant worldwide morbidity and mortality is still attributable to tobacco use in modern times. Research into tobacco products, the carcinogens they contain, and how users metabolize them is an important benefit to the advancement of research aimed at reducing harm associated with tobacco use. This review summarizes the use of this type of research to study tobacco users’ risk of developing cancer, especially head and neck cancer. In addition, we discuss the use of tobacco research to provide support for increasing levels of federal regulation of tobacco products. Level of Evidence: 4.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalLaryngoscope investigative otolaryngology
Volume3
Issue number5
DOIs
StatePublished - Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society.

Keywords

  • carcinogen
  • DNA adduct
  • Head and neck cancer
  • Level of Evidence
  • nitrosamines
  • tobacco

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