Tolerance to morphine analgesia: decreased multiplicative interaction between spinal and supraspinal sites

Sandra C. Roerig; Sandra M. O'Brien; James M. Fujimoto; George L. Wilcox

doi:10.1016/0006-8993(84)91078-3

Tolerance to morphine analgesia: decreased multiplicative interaction between spinal and supraspinal sites

Sandra C. Roerig, Sandra M. O'Brien, James M. Fujimoto, George L. Wilcox

Neuroscience

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Mice injected with morphine at both a supraspinal (intracerebroventricular)and a spinal (intrathecal) site showed a multiplicative interaction between sites for the tail-flick analgesic response. In morphine pellet-implanted mice, the decrease in this interaction was the source of tolerance developed to subcutaneous morphine whereas the separate sites showed no tolerance. During morphine withdrawal (after removal of the morphine pellet) synergism between sites returned but the separate sites showed development of tolerance.

Original language	English (US)
Pages (from-to)	360-363
Number of pages	4
Journal	Brain Research
Volume	308
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)91078-3
State	Published - Aug 13 1984

Bibliographical note

Funding Information:
The helpful suggestions of D. (;. Lange are greatly appreciated. This study was supported bv National Institute on Drug Abuse Grant DA 00451 and a Veterans Administration Research Career Scientist Award to J. M. F.

Keywords

morphine-analgesic tolerance
spinal/supraspinal multiplicity

Access

10.1016/0006-8993(84)91078-3

OpenUrl availability

Full text

Cite this

@article{a1b5bf47e05a4e37a21f7ef54b73fd6c,

title = "Tolerance to morphine analgesia: decreased multiplicative interaction between spinal and supraspinal sites",

abstract = "Mice injected with morphine at both a supraspinal (intracerebroventricular)and a spinal (intrathecal) site showed a multiplicative interaction between sites for the tail-flick analgesic response. In morphine pellet-implanted mice, the decrease in this interaction was the source of tolerance developed to subcutaneous morphine whereas the separate sites showed no tolerance. During morphine withdrawal (after removal of the morphine pellet) synergism between sites returned but the separate sites showed development of tolerance.",

keywords = "morphine-analgesic tolerance, spinal/supraspinal multiplicity",

author = "Roerig, {Sandra C.} and O'Brien, {Sandra M.} and Fujimoto, {James M.} and Wilcox, {George L.}",

note = "Funding Information: The helpful suggestions of D. (;. Lange are greatly appreciated. This study was supported bv National Institute on Drug Abuse Grant DA 00451 and a Veterans Administration Research Career Scientist Award to J. M. F.",

year = "1984",

month = aug,

day = "13",

doi = "10.1016/0006-8993(84)91078-3",

language = "English (US)",

volume = "308",

pages = "360--363",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Tolerance to morphine analgesia

T2 - decreased multiplicative interaction between spinal and supraspinal sites

AU - Roerig, Sandra C.

AU - O'Brien, Sandra M.

AU - Fujimoto, James M.

AU - Wilcox, George L.

N1 - Funding Information: The helpful suggestions of D. (;. Lange are greatly appreciated. This study was supported bv National Institute on Drug Abuse Grant DA 00451 and a Veterans Administration Research Career Scientist Award to J. M. F.

PY - 1984/8/13

Y1 - 1984/8/13

N2 - Mice injected with morphine at both a supraspinal (intracerebroventricular)and a spinal (intrathecal) site showed a multiplicative interaction between sites for the tail-flick analgesic response. In morphine pellet-implanted mice, the decrease in this interaction was the source of tolerance developed to subcutaneous morphine whereas the separate sites showed no tolerance. During morphine withdrawal (after removal of the morphine pellet) synergism between sites returned but the separate sites showed development of tolerance.

AB - Mice injected with morphine at both a supraspinal (intracerebroventricular)and a spinal (intrathecal) site showed a multiplicative interaction between sites for the tail-flick analgesic response. In morphine pellet-implanted mice, the decrease in this interaction was the source of tolerance developed to subcutaneous morphine whereas the separate sites showed no tolerance. During morphine withdrawal (after removal of the morphine pellet) synergism between sites returned but the separate sites showed development of tolerance.

KW - morphine-analgesic tolerance

KW - spinal/supraspinal multiplicity

UR - http://www.scopus.com/inward/record.url?scp=0021191841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021191841&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)91078-3

DO - 10.1016/0006-8993(84)91078-3

M3 - Article

C2 - 6548169

AN - SCOPUS:0021191841

SN - 0006-8993

VL - 308

SP - 360

EP - 363

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Tolerance to morphine analgesia: decreased multiplicative interaction between spinal and supraspinal sites

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this