Mapeo tonotópico de la cortezqon lesiones cocleares inducidas con amikacina

Translated title of the contribution: Tonotopic mapping in auditory cortex of the adult chinchilla with amikacin-induced cochlear lesions

Akinobu Kakigi, Haruo Hirakawa, Noam Harel, Richard J. Mount, Robert V. Harrison

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We have found a reorganization of tonotopic maps (based on neuron response thresholds) in primary auditory cortex of the adult chinchilla after amikacin-induced basal cochlear lesions. We find an over-representation of a frequency that corresponds to the border area of the cochlear lesion. The reorganization observed is similar in extent to that previously seen in a developmental model. The properties of neurons within the over-represented area were investigated in order to determine whether their responses originated from a common input (an indication of true plasticity) or represented only the result of truncating the activity of the sensory epithelium (“pseudo-plasticity”). Some aspects of our data fit with a true plasticity model and indicate the potential for the deafferented cortex of the mature cortex to regain connections with the surviving sensory epithelium.

Translated title of the contributionTonotopic mapping in auditory cortex of the adult chinchilla with amikacin-induced cochlear lesions
Original languageSpanish
Pages (from-to)153-160
Number of pages8
JournalInternational Journal of Phytoremediation
Volume39
Issue number3
DOIs
StatePublished - Jan 1 2000

Keywords

  • Amikacin
  • Aminoglycoside
  • Auditory brainstem response audiogram
  • Auditory cortex
  • Cochleogram
  • Cortical mapping
  • Ototoxicity
  • Plasticity
  • Scanning electron microscopy
  • Single-unit electrophysiology

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