Abstract
We have found a reorganization of tonotopic maps (based on neuron response thresholds) in primary auditory cortex of the adult chinchilla after amikacin-induced basal cochlear lesions. We find an over-representation of a frequency that corresponds to the border area of the cochlear lesion. The reorganization observed is similar in extent to that previously seen in a developmental model. The properties of neurons within the over-represented area were investigated in order to determine whether their responses originated from a common input (an indication of true plasticity) or represented only the result of truncating the activity of the sensory epithelium (“pseudo-plasticity”). Some aspects of our data fit with a true plasticity model and indicate the potential for the deafferented cortex of the mature cortex to regain connections with the surviving sensory epithelium.
Translated title of the contribution | Tonotopic mapping in auditory cortex of the adult chinchilla with amikacin-induced cochlear lesions |
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Original language | Spanish |
Pages (from-to) | 153-160 |
Number of pages | 8 |
Journal | International Journal of Phytoremediation |
Volume | 39 |
Issue number | 3 |
DOIs | |
State | Published - Jan 1 2000 |
Keywords
- Amikacin
- Aminoglycoside
- Auditory brainstem response audiogram
- Auditory cortex
- Cochleogram
- Cortical mapping
- Ototoxicity
- Plasticity
- Scanning electron microscopy
- Single-unit electrophysiology