TY - JOUR
T1 - Total Pancreatectomy with Intraportal Islet Autotransplantation as a Treatment of Chronic Pancreatitis in Patients with CFTR Mutations
AU - Colling, Kristin P.
AU - Bellin, Melena D.
AU - Schwarzenberg, Sarah J.
AU - Berry, Louise
AU - Wilhelm, Joshua J.
AU - Dunn, Ty
AU - Pruett, Timothy L.
AU - Sutherland, David E.R.
AU - Chinnakotla, Srinath
AU - Dunitz, Jordan M.
AU - Beilman, Greg J.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Objectives Chronic pancreatitis (CP) is an infrequent but debilitating complication associated with CFTR mutations. Total pancreatectomy with islet autotransplantation (TPIAT) is a treatment option for CP that provides pain relief and preserves β-cell mass, thereby minimizing the complication of diabetes mellitus. We compared outcomes after TPIAT for CP associated with CFTR mutations to CP without CTFR mutations. Methods All TPIATs performed between 2002 and 2014 were retrospectively reviewed: identifying 20 CFTR homozygotes (cystic fibrosis [CF] patients), 19 CFTR heterozygotes, and 20 age-/sex-matched controls without CFTR mutations. Analysis of variance and χ2 tests were used to compare groups. Results Baseline demographics were not different between groups. Postoperative glycosylated hemoglobin and C-peptide levels were similar between groups, as were islet yield and rate of postoperative complications. At 1 year, 40% of CF patients, 22% of CFTR heterozygotes, and 35% of control patients were insulin independent. Conclusion Total pancreatectomy with islet autotransplantation is a safe, effective treatment option for CF patients with CP, giving similar outcomes for those with other CP etiologies.
AB - Objectives Chronic pancreatitis (CP) is an infrequent but debilitating complication associated with CFTR mutations. Total pancreatectomy with islet autotransplantation (TPIAT) is a treatment option for CP that provides pain relief and preserves β-cell mass, thereby minimizing the complication of diabetes mellitus. We compared outcomes after TPIAT for CP associated with CFTR mutations to CP without CTFR mutations. Methods All TPIATs performed between 2002 and 2014 were retrospectively reviewed: identifying 20 CFTR homozygotes (cystic fibrosis [CF] patients), 19 CFTR heterozygotes, and 20 age-/sex-matched controls without CFTR mutations. Analysis of variance and χ2 tests were used to compare groups. Results Baseline demographics were not different between groups. Postoperative glycosylated hemoglobin and C-peptide levels were similar between groups, as were islet yield and rate of postoperative complications. At 1 year, 40% of CF patients, 22% of CFTR heterozygotes, and 35% of control patients were insulin independent. Conclusion Total pancreatectomy with islet autotransplantation is a safe, effective treatment option for CF patients with CP, giving similar outcomes for those with other CP etiologies.
KW - cystic fibrosis
KW - genetic pancreatitis
KW - islet cell transplant
KW - pancreatitis
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U2 - 10.1097/MPA.0000000000000968
DO - 10.1097/MPA.0000000000000968
M3 - Article
C2 - 29206667
AN - SCOPUS:85040971643
SN - 0885-3177
VL - 47
SP - 238
EP - 244
JO - Pancreas
JF - Pancreas
IS - 2
ER -