Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker working group report

Kirk R. Schultz, David B. Miklos, Daniel Fowler, Ken Cooke, Judith Shizuru, Emmanuel Zorn, Ernst Holler, James Ferrara, Howard Shulman, Stephanie J. Lee, Paul Martin, Alexandra H. Filipovich, Mary E D Flowers, Daniel Weisdorf, Daniel Couriel, Peter A. Lachenbruch, Barbara Mittleman, Georgia B. Vogelsang, Steven Z. Pavletic

Research output: Contribution to journalReview articlepeer-review

132 Scopus citations

Abstract

Biology-based markers that can be used to confirm the diagnosis of chronic graft-versus-host disease (GVHD) or monitor progression of the disease could help in the evaluation of new therapies. Biomarkers have been defined as any characteristic that is objectively measured and evaluated as an indicator of a normal biologic or pathogenic process, a pharmacologic response to a therapeutic intervention, or a surrogate end point intended to substitute for a clinical end point. The following applications of biomarkers could be useful in chronic GVHD clinical trials or management: (1) predicting response to therapy; (2) measuring disease activity and distinguishing irreversible damage from continued disease activity; (3) predicting the risk of developing chronic GVHD; (4) diagnosing chronic GVHD: (5) predicting the prognosis of chronic GVHD; (6) evaluating the balance between GVHD and graft-versus-leukemia effects (graft-versus-leukemia or GVT); and (7) serving as a surrogate end point for therapeutic response. Such biomarkers can be identified by either hypothesis-driven testing or by high-throughput discovery-based methods. To date, no validated biomarkers have been established for chronic GVHD, although several candidate biomarkers have been identified from limited hypothesis-driven studies. Both approaches have merit and should be pursued. The consistent treatment and standardized documentation needed to support biomarker studies are most likely to be satisfied in prospective clinical trials.

Original languageEnglish (US)
Pages (from-to)126-137
Number of pages12
JournalBiology of Blood and Marrow Transplantation
Volume12
Issue number2
DOIs
StatePublished - Feb 2006

Bibliographical note

Funding Information:
This project was supported by the National Institutes of Health (NIH) National Cancer Institute, Office of the Director, Cancer Therapy Evaluation Program, Intramural Research Program and Center for Cancer Research; National Heart Lung and Blood Institute, Division of Blood Diseases and Resources; Office of Rare Diseases, NIH, Office of the Director; National Institute of Allergy and Infectious Disease, Transplantation Immunology Branch; and the Health Resources and Services Administration, Division of Transplantation and the Naval Medical Research Center, C. W. Bill Young/Department of Defense Marrow Donor Recruitment and Research Program.

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Biomarkers
  • Graft-versus-host disease

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