Toward the development of solid-supported reagents for separation of alcohol-containing compounds by steric environment

Darci J. Trader, Erin E. Carlson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The affinity of silicon for oxygen has long been exploited to preferentially react hydroxyl moieties in the presence of others. Here, we explore the ability of a variety of dialkylsiloxane-functionalized resins to selectively capture and subsequently, release alcohol-containing compounds based on the steric environment about the silicon and hydroxyl moiety. The devised reagents will be applicable to the separation of compound mixtures, especially for the selective enrichment of low abundant molecules such as bioactive natural products.

Original languageEnglish (US)
Pages (from-to)4191-4196
Number of pages6
JournalTetrahedron
Volume70
Issue number27-28
DOIs
StatePublished - Jul 8 2014
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by an NSF CAREER Award, a Pew Biomedical Scholar Award (E.E.C.), and the Research Corporation for Science Advancement (Cottrell Scholar Award; E.E.C.).

Keywords

  • Hydroxyl group
  • Separations
  • Solid phase
  • Steric environment

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