Toward the development of solid-supported reagents for separation of alcohol-containing compounds by steric environment

Darci J. Trader; Erin E. Carlson

doi:10.1016/j.tet.2014.03.040

Toward the development of solid-supported reagents for separation of alcohol-containing compounds by steric environment

Darci J. Trader, Erin E. Carlson

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Abstract

The affinity of silicon for oxygen has long been exploited to preferentially react hydroxyl moieties in the presence of others. Here, we explore the ability of a variety of dialkylsiloxane-functionalized resins to selectively capture and subsequently, release alcohol-containing compounds based on the steric environment about the silicon and hydroxyl moiety. The devised reagents will be applicable to the separation of compound mixtures, especially for the selective enrichment of low abundant molecules such as bioactive natural products.

Original language	English (US)
Pages (from-to)	4191-4196
Number of pages	6
Journal	Tetrahedron
Volume	70
Issue number	27-28
DOIs	https://doi.org/10.1016/j.tet.2014.03.040
State	Published - Jul 8 2014
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by an NSF CAREER Award, a Pew Biomedical Scholar Award (E.E.C.), and the Research Corporation for Science Advancement (Cottrell Scholar Award; E.E.C.).

Keywords

Hydroxyl group
Separations
Solid phase
Steric environment

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abstract = "The affinity of silicon for oxygen has long been exploited to preferentially react hydroxyl moieties in the presence of others. Here, we explore the ability of a variety of dialkylsiloxane-functionalized resins to selectively capture and subsequently, release alcohol-containing compounds based on the steric environment about the silicon and hydroxyl moiety. The devised reagents will be applicable to the separation of compound mixtures, especially for the selective enrichment of low abundant molecules such as bioactive natural products.",

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AU - Trader, Darci J.

AU - Carlson, Erin E.

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N2 - The affinity of silicon for oxygen has long been exploited to preferentially react hydroxyl moieties in the presence of others. Here, we explore the ability of a variety of dialkylsiloxane-functionalized resins to selectively capture and subsequently, release alcohol-containing compounds based on the steric environment about the silicon and hydroxyl moiety. The devised reagents will be applicable to the separation of compound mixtures, especially for the selective enrichment of low abundant molecules such as bioactive natural products.

AB - The affinity of silicon for oxygen has long been exploited to preferentially react hydroxyl moieties in the presence of others. Here, we explore the ability of a variety of dialkylsiloxane-functionalized resins to selectively capture and subsequently, release alcohol-containing compounds based on the steric environment about the silicon and hydroxyl moiety. The devised reagents will be applicable to the separation of compound mixtures, especially for the selective enrichment of low abundant molecules such as bioactive natural products.

KW - Hydroxyl group

KW - Separations

KW - Solid phase

KW - Steric environment

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JO - Tetrahedron

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Toward the development of solid-supported reagents for separation of alcohol-containing compounds by steric environment

Abstract

Bibliographical note

Keywords

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