Towards a neurobiology of female aggression

Laura E. Been, Alison B. Gibbons, Robert L. Meisel

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Although many people think of aggression as a negative or undesirable emotion, it is a normal part of many species’ repertoire of social behaviors. Purposeful and controlled aggression can be adaptive in that it warns other individuals of perceived breaches in social contracts with the goal of dispersing conflict before it escalates into violence. Aggression becomes maladaptive, however, when it escalates inappropriately or impulsively into violence. Despite ample data demonstrating that impulsive aggression and violence occurs in both men and women, aggression has historically been considered a uniquely masculine trait. As a result, the vast majority of studies attempting to model social aggression in animals, particularly those aimed at understanding the neural underpinnings of aggression, have been conducted in male rodents. In this review, we summarize the state of the literature on the neurobiology of social aggression in female rodents, including social context, hormonal regulation and neural sites of aggression regulation. Our goal is to put historical research in the context of new research, emphasizing studies using ecologically valid methods and modern sophisticated techniques. This article is part of the Special Issue entitled ‘Current status of the neurobiology of aggression and impulsivity’.

Original languageEnglish (US)
Article number107451
JournalNeuropharmacology
Volume156
DOIs
StatePublished - Sep 15 2019

Bibliographical note

Funding Information:
This review and some of the research described were supported by the National Institutes of Health Grant DA013680 (RLM), the National Science Foundation Grant IOS 1256799 (RLM), and the Koshland Integrated Natural Sciences Center at Haverford College (LEB).

Funding Information:
This review and some of the research described were supported by the National Institutes of Health Grant DA013680 (RLM), the National Science Foundation Grant IOS 1256799 (RLM), and the Koshland Integrated Natural Sciences Center at Haverford College (LEB) .

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Animal models
  • Ecological context
  • Neural circuitry
  • Sex hormones
  • Social aggression

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