TY - JOUR
T1 - Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints
T2 - A brief discussion of concepts
AU - Ashauer, Roman
AU - Agatz, Annika
AU - Albert, Carlo
AU - Ducrot, Virginie
AU - Galic, Nika
AU - Hendriks, Jan
AU - Jager, Tjalling
AU - Kretschmann, Andreas
AU - O'Connor, Isabel
AU - Rubach, Mascha Nadine
AU - Nyman, Anna Maija
AU - Schmitt, Walter
AU - Stadnicka, Julita
AU - van den Brink, Paul J.
AU - Preuss, Thomas G.
PY - 2011/11
Y1 - 2011/11
N2 - We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined.
AB - We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined.
KW - Adverse outcome pathway
KW - Dose-response
KW - Dynamic energy budget
KW - Mechanistic effect model
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=80054098535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054098535&partnerID=8YFLogxK
U2 - 10.1002/etc.639
DO - 10.1002/etc.639
M3 - Article
C2 - 21805502
AN - SCOPUS:80054098535
SN - 0730-7268
VL - 30
SP - 2519
EP - 2524
JO - Environmental Toxicology and Chemistry
JF - Environmental Toxicology and Chemistry
IS - 11
ER -