Tracking the development of functional connectomes for face processing

Jane E. Joseph, Davy Vanderweyen, Joshua Swearingen, Brandon K. Vaughan, Derek Novo, Xun Zhu, Mulugeta Gebregziabher, Leonardo Bonilha, Ramesh Bhatt, Thomas Naselaris, Brian Dean

Research output: Contribution to journalArticlepeer-review

Abstract

Face processing capacities become more specialized and advanced during development, but neural underpinnings of these processes are not fully understood. The present study applied graph theory-based network analysis to task-negative (resting blocks) and task-positive (viewing faces) functional magnetic resonance imaging data in children (5-17 years) and adults (18-42 years) to test the hypothesis that the development of a specialized network for face processing is driven by task-positive processing (face viewing) more than by task-negative processing (visual fixation) and by both progressive and regressive changes in network properties. Predictive modeling was used to predict age from node-based network properties derived from task-positive and task-negative states in a whole-brain network (WBN) and a canonical face network (FN). The best-fitting model indicated that FN maturation was marked by both progressive and regressive changes in information diffusion (eigenvector centrality) in the task-positive state, with regressive changes outweighing progressive changes. Hence, FN maturation was characterized by reductions in information diffusion potentially reflecting the development of more specialized modules. In contrast, WBN maturation was marked by a balance of progressive and regressive changes in hub-connectivity (betweenness centrality) in the task-negative state. These findings suggest that the development of specialized networks like the FN depends on dynamic developmental changes associated with domain-specific information (e.g., face processing), but maturation of the brain as a whole can be predicted from task-free states.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalBrain connectivity
Volume9
Issue number2
DOIs
StatePublished - Mar 2019
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the National Institute of Child Health and Human Development (R01 HD05272 and R01 HD042452) and Autism Speaks (Pilot Award 1902). We thank Jonathan Clark, Christine Corbly, Myra Huffman, Nathan Johnson, and Melissa Wheatley for their assistance with data collection. We are also grateful to the families that volunteered for this study.

Publisher Copyright:
© 2019 Mary Ann Liebert, Inc., publishers.

Keywords

  • connectome
  • fMRI
  • face perception
  • functional connectivity
  • graph theory

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