TY - JOUR
T1 - Traditional Medicine Collection Tracking System (TM-CTS)
T2 - A database for ethnobotanically driven drug-discovery programs
AU - Harris, Eric S.J.
AU - Erickson, Sean D.
AU - Tolopko, Andrew N.
AU - Cao, Shugeng
AU - Craycroft, Jane A.
AU - Scholten, Robert
AU - Fu, Yanling
AU - Wang, Wenquan
AU - Liu, Yong
AU - Zhao, Zhongzhen
AU - Clardy, Jon
AU - Shamu, Caroline E.
AU - Eisenberg, David M.
N1 - Funding Information:
This work was supported primarily by a grant from the National Institutes of Health ( U19 CA128534 ) and also received partial support from the Osher Foundation.
PY - 2011/5/17
Y1 - 2011/5/17
N2 - Ethnopharmacological relevance: Ethnobotanically driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. Materials and methods: The system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat. Results: The TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. The system incorporates a number of unique features that are useful in the context of ethnobotanical projects such as support for information about botanical collection, method of processing, quality tests for plants with existing pharmacopoeia standards, chemical extraction and fractionation, and historical uses of the plants. The database also accommodates data provided in multiple languages and integration with a database system built to support high throughput screening based drug discovery efforts. It is accessed via a web-based application that provides extensive, multi-format reporting capabilities. Conclusions: This new database system was designed to support a project evaluating the bioactivity of Chinese medicinal plants. The software used to create the database is open source, freely available, and could potentially be applied to other ethnobotanically driven natural product collection and drug-discovery programs.
AB - Ethnopharmacological relevance: Ethnobotanically driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. Materials and methods: The system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat. Results: The TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. The system incorporates a number of unique features that are useful in the context of ethnobotanical projects such as support for information about botanical collection, method of processing, quality tests for plants with existing pharmacopoeia standards, chemical extraction and fractionation, and historical uses of the plants. The database also accommodates data provided in multiple languages and integration with a database system built to support high throughput screening based drug discovery efforts. It is accessed via a web-based application that provides extensive, multi-format reporting capabilities. Conclusions: This new database system was designed to support a project evaluating the bioactivity of Chinese medicinal plants. The software used to create the database is open source, freely available, and could potentially be applied to other ethnobotanically driven natural product collection and drug-discovery programs.
KW - Database
KW - Drug discovery
KW - Ethnobotany
KW - High throughput screening
KW - Traditional Chinese Medicine
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U2 - 10.1016/j.jep.2011.03.029
DO - 10.1016/j.jep.2011.03.029
M3 - Article
C2 - 21420479
AN - SCOPUS:79955690966
SN - 0378-8741
VL - 135
SP - 590
EP - 593
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -