Trait anger modulates neural activity in the fronto-parietal attention network

Nelly Alia-Klein; Rebecca N. Preston-Campbell; Scott J. Moeller; Muhammad A. Parvaz; Keren Bachi; Gabriela Gan; Anna Zilverstand; Anna B. Konova; Rita Z. Goldstein

doi:10.1371/journal.pone.0194444

Trait anger modulates neural activity in the fronto-parietal attention network

Nelly Alia-Klein, Rebecca N. Preston-Campbell, Scott J. Moeller, Muhammad A. Parvaz, Keren Bachi, Gabriela Gan, Anna Zilverstand, Anna B. Konova, Rita Z. Goldstein

Psychiatry & Behavioral Sciences

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15 Scopus citations

Abstract

Anger is considered a unique high-arousal and approach-related negative emotion. The influence of individual differences in trait anger on the processing of visual stimuli is relevant to questions about emotional processing and remains to be explored. Using functional magnetic resonance imaging (fMRI), we explored the neural responses to standardized images, selected based on valence and arousal ratings in a group of men with high trait anger compared to those with normative to low anger scores (controls). Results show increased activation in the left-lateralized ventral fronto-parietal attention network to unpleasant images by individuals with high trait anger. There was also a group by arousal interaction in the left thalamus/pulvinar such that individuals with high trait anger had increased pulvinar activation to the high-arousal (versus low arousal) unpleasant images as compared to controls. Thus, individual differences in trait anger in men are associated with brain regions subserving executive attentional and sensory integration during the processing of unpleasant emotional stimuli, particularly to high arousal images.

Original language	English (US)
Article number	e0194444
Journal	PloS one
Volume	13
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0194444
State	Published - Apr 2018

Bibliographical note

Funding Information:
This work was supported by a grant from the National Institute of Health (nih.gov; R01MH090134 to N.A.K.) and grants from the National Institute on Drug Abuse (drugabuse.gov; 5T32DA007135-32 to R.P-C., K01DA037452 to S. J.M., F32DA033088 to M.A.P.). This work was supported by a grant from the National Institute of Health (nih.gov; R01MH090134 to N.A.K.) and grants from the National Institute on Drug Abuse (drugabuse. gov; 5T32DA007135-32 to R.P-C., K01DA037452 to S.J.M., F32DA033088 to M.A.P., and T32-DA007135-31 to K.B.).

Publisher Copyright:
© 2018 Alia-Klein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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title = "Trait anger modulates neural activity in the fronto-parietal attention network",

abstract = "Anger is considered a unique high-arousal and approach-related negative emotion. The influence of individual differences in trait anger on the processing of visual stimuli is relevant to questions about emotional processing and remains to be explored. Using functional magnetic resonance imaging (fMRI), we explored the neural responses to standardized images, selected based on valence and arousal ratings in a group of men with high trait anger compared to those with normative to low anger scores (controls). Results show increased activation in the left-lateralized ventral fronto-parietal attention network to unpleasant images by individuals with high trait anger. There was also a group by arousal interaction in the left thalamus/pulvinar such that individuals with high trait anger had increased pulvinar activation to the high-arousal (versus low arousal) unpleasant images as compared to controls. Thus, individual differences in trait anger in men are associated with brain regions subserving executive attentional and sensory integration during the processing of unpleasant emotional stimuli, particularly to high arousal images.",

author = "Nelly Alia-Klein and Preston-Campbell, {Rebecca N.} and Moeller, {Scott J.} and Parvaz, {Muhammad A.} and Keren Bachi and Gabriela Gan and Anna Zilverstand and Konova, {Anna B.} and Goldstein, {Rita Z.}",

note = "Funding Information: This work was supported by a grant from the National Institute of Health (nih.gov; R01MH090134 to N.A.K.) and grants from the National Institute on Drug Abuse (drugabuse.gov; 5T32DA007135-32 to R.P-C., K01DA037452 to S. J.M., F32DA033088 to M.A.P.). This work was supported by a grant from the National Institute of Health (nih.gov; R01MH090134 to N.A.K.) and grants from the National Institute on Drug Abuse (drugabuse. gov; 5T32DA007135-32 to R.P-C., K01DA037452 to S.J.M., F32DA033088 to M.A.P., and T32-DA007135-31 to K.B.). Publisher Copyright: {\textcopyright} 2018 Alia-Klein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

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Trait anger modulates neural activity in the fronto-parietal attention network

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