Transcranial electrical stimulation of the occipital cortex during visual perception modifies the magnitude of BOLD activity: A combined tES–fMRI approach

Ivan Alekseichuk, Kersten Diers, Walter Paulus, Andrea Antal

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The aim of this study was to investigate if the blood oxygenation level-dependent (BOLD) changes in the visual cortex can be used as biomarkers reflecting the online and offline effects of transcranial electrical stimulation (tES). Anodal transcranial direct current stimulation (tDCS) and 10 Hz transcranial alternating current stimulation (tACS) were applied for 10 min duration over the occipital cortex of healthy adults during the presentation of different visual stimuli, using a crossover, double-blinded design. Control experiments were also performed, in which sham stimulation as well as another electrode montage were used. Anodal tDCS over the visual cortex induced a small but significant further increase in BOLD response evoked by a visual stimulus; however, no aftereffect was observed. Ten hertz of tACS did not result in an online effect, but in a widespread offline BOLD decrease over the occipital, temporal, and frontal areas. These findings demonstrate that tES during visual perception affects the neuronal metabolism, which can be detected with functional magnetic resonance imaging (fMRI).

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalNeuroImage
Volume140
DOIs
StatePublished - Oct 15 2016

Bibliographical note

Funding Information:
This study was supported by the DFG (PA 419/15-1) awarded to WP.

Keywords

  • fMRI
  • Occipital cortex
  • tACS
  • tDCS
  • Visual perception

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