TY - JOUR
T1 - Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes
AU - Kho, Alvin T.
AU - Kang, Peter B.
AU - Kohane, Isaac S.
AU - Kunkel, Louis M.
PY - 2006/3/7
Y1 - 2006/3/7
N2 - Background: Mouse and human skeletal muscle transcriptome profiles vary by muscle type, raising the question of which mouse muscle groups have the greatest molecular similarities to human skeletal muscle. Methods: Orthologous (whole, sub-) transcriptome profiles were compared among four mouse-human transcriptome datasets: (M) six muscle groups obtained from three mouse strains (wildtype, mdx, mdx5cv); (H1) biopsied human quadriceps from controls and Duchenne muscular dystrophy patients; (H2) four different control human muscle types obtained at autopsy; and (H3) 12 different control human tissues (ten non-muscle). Results: Of the six mouse muscles examined, mouse soleus bore the greatest molecular similarities to human skeletal muscles, independent of the latters' anatomic location/muscle type, disease state, age and sampling method (autopsy versus biopsy). Significant similarity to any one mouse muscle group was not observed for non-muscle human tissues (dataset H3), indicating this finding to be muscle specific. Conclusion: This observation may be partly explained by the higher type I fiber content of soleus relative to the other mouse muscles sampled.
AB - Background: Mouse and human skeletal muscle transcriptome profiles vary by muscle type, raising the question of which mouse muscle groups have the greatest molecular similarities to human skeletal muscle. Methods: Orthologous (whole, sub-) transcriptome profiles were compared among four mouse-human transcriptome datasets: (M) six muscle groups obtained from three mouse strains (wildtype, mdx, mdx5cv); (H1) biopsied human quadriceps from controls and Duchenne muscular dystrophy patients; (H2) four different control human muscle types obtained at autopsy; and (H3) 12 different control human tissues (ten non-muscle). Results: Of the six mouse muscles examined, mouse soleus bore the greatest molecular similarities to human skeletal muscles, independent of the latters' anatomic location/muscle type, disease state, age and sampling method (autopsy versus biopsy). Significant similarity to any one mouse muscle group was not observed for non-muscle human tissues (dataset H3), indicating this finding to be muscle specific. Conclusion: This observation may be partly explained by the higher type I fiber content of soleus relative to the other mouse muscles sampled.
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U2 - 10.1186/1471-2474-7-23
DO - 10.1186/1471-2474-7-23
M3 - Article
C2 - 16522209
AN - SCOPUS:33746735537
SN - 1471-2474
VL - 7
JO - BMC Musculoskeletal Disorders
JF - BMC Musculoskeletal Disorders
M1 - 23
ER -