This article is an essay that discusses the concepts underlying the application of modern transition state theory to reactions in enzymes. Issues covered include the potential of mean force, the quantization of vibrations, the free energy of activation, and transmission coefficients to account for nonequilibrium effect, recrossing, and tunneling.
Bibliographical noteFunding Information:
This work was supported in part by the National Institutes of Health through Grant No. NIGMS/1RC1GM091445 .
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- Enzyme kinetics
- Free energy
- Quantum effects
- Transition state theory