Treatment and Prophylaxis of Cytomegalovirus Disease

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10 Scopus citations

Abstract

The diseases caused by cytomegalovirus (CMV) may threaten the life or sight of immunocompromised individuals such as patients undergoing transplantation and those with the acquired immunodeficiency syndrome. The management of CMV disease can be difficult. The antiviral agents ganciclovir and foscarnet are effective against CMV retinitis and gastrointestinal diseases, although dose‐limiting adverse effects and the need for long‐term maintenance therapy may hinder their use in many patients. When used to treat CMV pneumonitis in bone marrow transplant recipients, ganciclovir alone is not as effective as when it is combined with immune globulin. Since CMV disease can be fatal, several protocols have been developed for the transplant patient population, including administration of acyclovir, ganciclovir, screened blood products, and immune globulins. 1992 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)300-318
Number of pages19
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1992

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