TY - JOUR
T1 - Treatment of melanoma-associated retinopathy
AU - Powell, Steven F.
AU - Dudek, Arkadiusz Z
PY - 2010/1
Y1 - 2010/1
N2 - Opinion statement: Melanoma-associated retinopathy is a rare paraneoplastic disorder that is challenging to diagnose and even more difficult to treat. Because of the rarity of the disease, therapy is based on analysis of case series and case reports. Based on evidence from these reports, first-line therapy is cytoreduction of metastatic disease through metastasectomy, chemotherapy, and radiation. This can be combined with intravenous immunoglobulin. For refractory visual symptoms, additional therapies include systemic corticosteroids and plasmapheresis, but the success of these strategies has been limited. Because of the rarity of the disorder, new therapies should be evaluated and reported in the literature to expand our clinical understanding of this autoimmune disease.
AB - Opinion statement: Melanoma-associated retinopathy is a rare paraneoplastic disorder that is challenging to diagnose and even more difficult to treat. Because of the rarity of the disease, therapy is based on analysis of case series and case reports. Based on evidence from these reports, first-line therapy is cytoreduction of metastatic disease through metastasectomy, chemotherapy, and radiation. This can be combined with intravenous immunoglobulin. For refractory visual symptoms, additional therapies include systemic corticosteroids and plasmapheresis, but the success of these strategies has been limited. Because of the rarity of the disorder, new therapies should be evaluated and reported in the literature to expand our clinical understanding of this autoimmune disease.
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U2 - 10.1007/s11940-009-0057-x
DO - 10.1007/s11940-009-0057-x
M3 - Review article
C2 - 20842490
AN - SCOPUS:77649271969
SN - 1092-8480
VL - 12
SP - 54
EP - 63
JO - Current Treatment Options in Neurology
JF - Current Treatment Options in Neurology
IS - 1
ER -