Tri-, tetra- and pentapeptidoylbenzotriazoles: Novel synthetic intermediates

Abdelmotaal Abdelmajeid, Srinivasa Tala, M. S. Amine, Alan R. Katritzky

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Conveniently synthesized novel N-(protected α-tri-, tetra- and pentapeptidoyl)benzotriazoles couple in aqueous aceto-nitrile solution at 0C with free amino acids, dipeptides, and tripeptides- to afford N-terminal-protected polypeptides (61-92%) including those containing unprotected OH, SH, and indole NH groups, with no detectable racemization.

Original languageEnglish (US)
Article numberM61111SS
Pages (from-to)2995-3005
Number of pages11
JournalSynthesis
Issue number18
DOIs
StatePublished - Aug 25 2011

Keywords

  • acylation
  • amino acids
  • coupling
  • medicinal chemistry
  • peptides

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