Abstract
Conveniently synthesized novel N-(protected α-tri-, tetra- and pentapeptidoyl)benzotriazoles couple in aqueous aceto-nitrile solution at 0C with free amino acids, dipeptides, and tripeptides- to afford N-terminal-protected polypeptides (61-92%) including those containing unprotected OH, SH, and indole NH groups, with no detectable racemization.
Original language | English (US) |
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Article number | M61111SS |
Pages (from-to) | 2995-3005 |
Number of pages | 11 |
Journal | Synthesis |
Issue number | 18 |
DOIs | |
State | Published - 2011 |
Bibliographical note
Copyright:Copyright 2011 Elsevier B.V., All rights reserved.
Keywords
- acylation
- amino acids
- coupling
- medicinal chemistry
- peptides