Abstract
Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.
Original language | English (US) |
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Pages (from-to) | 542-545 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2011 |
Bibliographical note
Funding Information:Supported by the Continuing Umbrella of Research Experiences Supplement to NIH T32 CA09138 (Cancer Biology Training Grant) (to CDR), NIH Supplement to NIH GM56615 to Promote Diversity in Health-Related Research (to CDR), and a Natural Resources Research Institute funding agreement.
Keywords
- Antiretroviral
- Antiviral
- Protease
- Proteolysis
- Retrovirus