Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.
Bibliographical noteFunding Information:
Supported by the Continuing Umbrella of Research Experiences Supplement to NIH T32 CA09138 (Cancer Biology Training Grant) (to CDR), NIH Supplement to NIH GM56615 to Promote Diversity in Health-Related Research (to CDR), and a Natural Resources Research Institute funding agreement.