Background: β3-Adrenergic receptor (β3-AR) gene is associated with insulin resistance and may affect serum uric acid levels. Our aim was to determine the possible association between β3-AR gene Trp64Arg polymorphism (rs4994) and hyperuricemia in a Chinese male population. Methods: A total of 410 hyperuricemic and 420 normouricemic male subjects were genotyped in this study. The genotypic and allelic frequencies were compared between the two groups. Body mass index (BMI), waist to hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum uric acid, urea nitrogen, creatinine, triglyceride, total cholesterol, low-density lipoprotein- cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and fasting plasma glucose (FPG) were determined. Results: The frequencies of CC genotype and C allele for Trp64Arg polymorphism were higher in hyperuricemic group than in normouricemic group (p <; 0.01 and p <; 0.05, respectively). In both hyperuricemic and normouricemic groups, subjects with mutated C allele of Trp64Arg polymorphism showed significantly higher average uric acid levels than TT genotype carriers (p <; 0.01 and p <; 0.01, respectively). Univariate and multivariate logistic regression showed that carrier of mutated C allele of Trp64Arg polymorphism was significantly associated with hyperuricemia occurrence (p = 0.003, OR = 1.587, 95% CI 1.175- 2.145 and p = 0.003, OR = 1.676, 95% CI 1.051-3.617). Conclusions: Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population and should be an independent risk factor for hyperuricemia.
Bibliographical noteFunding Information:
Acknowledgments: This study was supported by the National Natural Science Foundation of China Grants 81202596 and 81202541, Specialized Research Fund for the Doctoral Program of Higher Education (20113420120006), Grants for Scientific Research of BSKY (XJ201021), Research Foundation of Anhui Medical University (2011xkj011), Anhui province Nature Science Foundation in University (KJ2012Z158), Young top-notch talent support programs from Anhui Medical University (2012) and Foundation for Key Teacher by Anhui Medical University (2013).
- β3-adrenergic receptor
- Association analysis
- Genetic polymorphism
- Serum uric acid