A panel of derivatives of the natural product tryptanthrin was synthesized and screened for its in vitro activity against the intracellular parasite Toxoplasma gondii. We concentrated on the modification of the 6-keto group of tryptanthrin and prepared a series of oximes, hydrazones and alcohols based on tryptanthrin. We evaluated parasite growth inhibition and host cell cytotoxicity. Our results indicate that in particular alcohol analogs are promising candidates for further investigation.
Bibliographical noteFunding Information:
This work was supported by Stanley Medical Research Institute.
Copyright 2013 Elsevier B.V., All rights reserved.
- Inhibition of parasite growth
- Natural product
- Toxoplasma gondii