T and T MRI in the evaluation of parkinson's disease

Igor Nestrasil, Shalom Michaeli, T. Liimatainen, C. E. Rydeen, Catherine M Kotz, J. P. Nixon, T. Hanson, Paul J Tuite

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Prior work has shown that adiabatic T and T relaxation time constants may have sensitivity to cellular changes and the presence of iron, respectively, in Parkinson's disease (PD). Further understanding of these magnetic resonance imaging (MRI) methods and how they relate to measures of disease severity and progression in PD is needed. Using T and T on a 4T MRI scanner, we assessed the substantia nigra (SN) of nine non-demented moderately affected PD and ten gender- and age-matched control participants. When compared to controls, the SN of PD subjects had increased T and reduced T. We also found a significant correlation between asymmetric motor features and asymmetry based on T. This study provides additional validation of T and T as a means to separate PD from control subjects, and T may be a useful marker of asymmetry in PD.

Original languageEnglish (US)
Pages (from-to)964-968
Number of pages5
JournalJournal of Neurology
Volume257
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • Biomarker
  • High-field MRI
  • Iron
  • Magnetic resonance imaging
  • Parkinson's disease

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