Abstract
Immunodeficient patients are at an increased risk of developing Epstein-Barr virus (EBV) associated lymphomas. We report a patient with X-linked severe combined immunodeficiency (X-SCID), who presented with an EBV-negative, B-cell non-Hodgkin lymphoma. The tumor did not resolve with chemotherapy or rituximab, but only after recovery of functional donor T-cells cell following hematopoietic stem cell transplantation (HSCT). This case illustrates that the cancer predilection associated with immunodeficient hosts may not be a specific immune defect in the recognition of viral specific antigens, and it could be a defect in immune surveillance necessary for elimination of cells with abnormalities in proliferation, function and/or apoptosis.
Original language | English (US) |
---|---|
Pages (from-to) | 706-709 |
Number of pages | 4 |
Journal | Pediatric Blood and Cancer |
Volume | 51 |
Issue number | 5 |
DOIs | |
State | Published - Nov 2008 |
Externally published | Yes |
Keywords
- EBV
- SCID
- Tumor immune surveillance