Abstract
The tumor initiating activities of 5,11-dimethylchrysene and 5-methylchrysene on mouse skin were compared. After initiating doses of 30 μg or 10 μg, with promotion by 3 times weekly applications of tetradecanoylphorbol acetate, both compounds were highly tumorigenic, inducing tumors in 70-85% of the treated animals. Since 5,12-dimethylchrysene had previously been shown to be only a weak tumor initiator, these results support the generalization that the structural requirements favoring carcinogenicity among the methylated chrysenes and other polynuclear aromatic hydrocarbons (PAH) are a bay region methyl group and a free peri position, both adjacent to an unsubstituted angular ring.
Original language | English (US) |
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Pages (from-to) | 65-70 |
Number of pages | 6 |
Journal | Cancer Letters |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - Nov 1979 |
Bibliographical note
Funding Information:This study was supported by Grant CA-012376 from the National Cancer Institute. Stephen S. Hecht is recipient of the National Cancer Institute Research Career ~velopment Award No. 5KO4 CA-00124.