TY - JOUR
T1 - Tumor necrosis factor-α increases hepatic DNA and RNA and hepatocyte mitosis
AU - Beyer, H. S.
AU - Stanley, M.
AU - Theologides, A.
PY - 1990
Y1 - 1990
N2 - Tumor necrosis factor-α (TNF) has been reported to increase DNA synthesis in normal rat liver. Therefore, we examined the effects of TNF on rat liver regeneration. TNF, 1.5 μg ip every 4 h for 5 d, significantly increased hepatic DNA and RNA contents of regenerating and sham operated livers by up to 45%. Mitotic figures in sham operated liver, usually rare, were increased substantially by TNF. ODC mRNA content and enzyme activity were increased in regenerating liver, and were further increased by TNF. These data indicate that TNF, although not specific for regenerating liver, is a potent stimulus for hepatocyte DNA synthesis and mitosis.
AB - Tumor necrosis factor-α (TNF) has been reported to increase DNA synthesis in normal rat liver. Therefore, we examined the effects of TNF on rat liver regeneration. TNF, 1.5 μg ip every 4 h for 5 d, significantly increased hepatic DNA and RNA contents of regenerating and sham operated livers by up to 45%. Mitotic figures in sham operated liver, usually rare, were increased substantially by TNF. ODC mRNA content and enzyme activity were increased in regenerating liver, and were further increased by TNF. These data indicate that TNF, although not specific for regenerating liver, is a potent stimulus for hepatocyte DNA synthesis and mitosis.
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M3 - Article
C2 - 1706180
AN - SCOPUS:0025686106
SN - 0158-5231
VL - 22
SP - 405
EP - 410
JO - Biochemistry International
JF - Biochemistry International
IS - 3
ER -