Tuning the coordination number of hydroxypyridonate-based gadolinium complexes: Implications for MRI contrast agents

Valérie C. Pierre, Mauro Botta, Silvio Aime, Kenneth N. Raymond

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Eight-coordinate hydroxypyridinone/terephthalamide GdIII complexes display high relaxivities due to their two inner sphere water molecules. This relaxivity can be further increased by functionalizing the terephthalamide moiety with an amine. A significant hydrogen bonding interaction between the amine and another water molecule close to the GdIII apparently facilitates its coordination on the open site of the metal. The resulting nine-coordinate complex has three inner sphere water molecules, while maintaining high stability and fast ligand exchange rates.

Original languageEnglish (US)
Pages (from-to)5344-5345
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number16
DOIs
StatePublished - Apr 26 2006

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