TY - JOUR
T1 - Tv viewing and incident venous thromboembolism
T2 - The atherosclerotic risk in communities study
AU - Kubota, Yasuhiko
AU - Cushman, Mary
AU - Zakai, Neil
AU - Rosamond, Wayne D.
AU - Folsom, Aaron R
N1 - Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2018.
PY - 2018/4
Y1 - 2018/4
N2 - TV viewing is associated with risk of arterial vascular diseases, but has not been evaluated in relation to venous throm-boembolism (VTE) risk in Western populations. In 1987–1989, the Atherosclerosis Risk in Communities Study obtained information on the frequency of TV viewing in participants aged 45–64 and followed them prospectively. In individuals free of prebaseline VTE (n=15, 158), we used a Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident VTE according to frequency of TV viewing (“Never or seldom”, “Sometimes”, “Often” or “Very often”). During the 299,767 person-years of follow-up, we identified 691 VTE events. In a multivariable-adjusted model, the frequency of TV viewing showed a positive dose–response relation with VTE incidence (P for trend=0.036), in which “very often” viewing TV carried 1.71 (95% CI 1.26–2.32) times the risk of VTE compared with “never or seldom” viewing TV. This association to some degree was mediated by obesity (25% mediation, 95% CI 10.7–27.5). Even among individuals who met a recommended level of physical activity, viewing TV “very often” carried 1.80 (1.04–3.09) times the risk of VTE, compared to viewing TV “never or seldom”. Greater frequency of TV viewing was independently associated with increased risk of VTE, partially mediated by obesity. Achieving a recommended physical activity level did not eliminate the increased VTE risk associated with frequent TV viewing. Avoiding frequent TV viewing as well as increasing physical activity and controlling body weight might be beneficial for VTE prevention.
AB - TV viewing is associated with risk of arterial vascular diseases, but has not been evaluated in relation to venous throm-boembolism (VTE) risk in Western populations. In 1987–1989, the Atherosclerosis Risk in Communities Study obtained information on the frequency of TV viewing in participants aged 45–64 and followed them prospectively. In individuals free of prebaseline VTE (n=15, 158), we used a Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident VTE according to frequency of TV viewing (“Never or seldom”, “Sometimes”, “Often” or “Very often”). During the 299,767 person-years of follow-up, we identified 691 VTE events. In a multivariable-adjusted model, the frequency of TV viewing showed a positive dose–response relation with VTE incidence (P for trend=0.036), in which “very often” viewing TV carried 1.71 (95% CI 1.26–2.32) times the risk of VTE compared with “never or seldom” viewing TV. This association to some degree was mediated by obesity (25% mediation, 95% CI 10.7–27.5). Even among individuals who met a recommended level of physical activity, viewing TV “very often” carried 1.80 (1.04–3.09) times the risk of VTE, compared to viewing TV “never or seldom”. Greater frequency of TV viewing was independently associated with increased risk of VTE, partially mediated by obesity. Achieving a recommended physical activity level did not eliminate the increased VTE risk associated with frequent TV viewing. Avoiding frequent TV viewing as well as increasing physical activity and controlling body weight might be beneficial for VTE prevention.
KW - TV Venous thromboembolism Physical activity Sedentary behavior
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U2 - 10.1007/s11239-018-1620-7
DO - 10.1007/s11239-018-1620-7
M3 - Article
C2 - 29468488
AN - SCOPUS:85042228568
SN - 0929-5305
VL - 45
SP - 353
EP - 359
JO - Journal of thrombosis and thrombolysis
JF - Journal of thrombosis and thrombolysis
IS - 3
ER -
