TY - JOUR
T1 - Twenty-four-hour ambulatory blood pressure monitoring efficacy of perindopril/indapamide first-line combination in hypertensive patients
T2 - The REASON study
AU - Mallion, Jean Michel
AU - Chamontin, Bernard
AU - Asmar, Roland
AU - De Leeuw, Peter Wilhelmus
AU - O'Brien, Eoin
AU - Duprez, Daniel
AU - O'Rourke, Michael F.
AU - Rahn, Karl Heinz
AU - Romero, Ramon
AU - Battegay, Edouard
AU - Hitzenberger, Gerhart
AU - Safar, Michel E.
N1 - Funding Information:
This study was supported by Institut de Recherches Internationales Servier, Courbevoie, France.
PY - 2004/3
Y1 - 2004/3
N2 - Background: Circadian blood pressure (BP) measurements provide more information on hypertensive complications than office BP measurements. The purpose of this study was to analyze the efficacy of the first-line combination of perindopril 2 mg plus indapamide 0.625 mg versus atenolol 50 mg on BP parameters and variability over 24 h in patients with hypertension. Methods: A double-blind, randomized, controlled, 12-month study comparing perindopril/indapamide and atenolol was performed in 201 patients (age 55.0 years) with uncomplicated sustained essential hypertension. Ambulatory BP measurements (ABPM) were done every 15 min over 24 h. Results: After 1 year of treatment, the decrease in systolic BP was significantly greater for perindopril/indapamide than for atenolol during the entire 24-h period (-13.8 v -9.2 mm Hg), the daytime and the nighttime periods (P < .01). Diastolic blood pressure (DBP) variations were comparable for the two groups (-7.2 v -8.3 mm Hg, NS). Pulse pressure (PP) reduction was also significantly greater for perindopril/indapamide than for atenolol (for the whole 24 h, -6.6 v -0.9 mm Hg, P < .001). The through to peak (T/P) BP ratio and the smoothness index were comparable in the two groups for DBP. For systolic blood pressure (SBP), higher values of the T/P ratio (0.80 v 0.59) and the smoothness index (1.45 v 0.98; P < .02) were achieved for the perindopril/indapamide combination than for atenolol. Conclusions: The perindopril/indapamide first-line combination decreased SBP and PP more effectively than atenolol. Moreover, the BP control effect was smooth and consistent throughout the 24-h dosing interval and BP reduction variability was lower than the one induced by atenolol.
AB - Background: Circadian blood pressure (BP) measurements provide more information on hypertensive complications than office BP measurements. The purpose of this study was to analyze the efficacy of the first-line combination of perindopril 2 mg plus indapamide 0.625 mg versus atenolol 50 mg on BP parameters and variability over 24 h in patients with hypertension. Methods: A double-blind, randomized, controlled, 12-month study comparing perindopril/indapamide and atenolol was performed in 201 patients (age 55.0 years) with uncomplicated sustained essential hypertension. Ambulatory BP measurements (ABPM) were done every 15 min over 24 h. Results: After 1 year of treatment, the decrease in systolic BP was significantly greater for perindopril/indapamide than for atenolol during the entire 24-h period (-13.8 v -9.2 mm Hg), the daytime and the nighttime periods (P < .01). Diastolic blood pressure (DBP) variations were comparable for the two groups (-7.2 v -8.3 mm Hg, NS). Pulse pressure (PP) reduction was also significantly greater for perindopril/indapamide than for atenolol (for the whole 24 h, -6.6 v -0.9 mm Hg, P < .001). The through to peak (T/P) BP ratio and the smoothness index were comparable in the two groups for DBP. For systolic blood pressure (SBP), higher values of the T/P ratio (0.80 v 0.59) and the smoothness index (1.45 v 0.98; P < .02) were achieved for the perindopril/indapamide combination than for atenolol. Conclusions: The perindopril/indapamide first-line combination decreased SBP and PP more effectively than atenolol. Moreover, the BP control effect was smooth and consistent throughout the 24-h dosing interval and BP reduction variability was lower than the one induced by atenolol.
KW - Ambulatory blood pressure measurement
KW - Antihypertensive drug treatment
KW - Blood pressure variability
KW - Perindopril/indapamide combination
KW - Smoothness index
KW - Trough/peak ratio
UR - http://www.scopus.com/inward/record.url?scp=10744229582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744229582&partnerID=8YFLogxK
U2 - 10.1016/j.amjhyper.2003.11.001
DO - 10.1016/j.amjhyper.2003.11.001
M3 - Article
C2 - 15001199
AN - SCOPUS:10744229582
SN - 0895-7061
VL - 17
SP - 245
EP - 251
JO - American journal of hypertension
JF - American journal of hypertension
IS - 3
ER -