Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH

Yingying Lu, Bai Xia Hao, Richard Graeff, Connie W.M. Wong, Wu Tian Wu, Jianbo Yue

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Background: The role and mechanism of NAADP, an endogenous Ca2+ mobilizing nucleotide, in autophagic regulation remain to be determined. Results: Activation of NAADP/TPC2 signaling induced the accumulation of autophagosomes. Conclusion: The NAADP/TPC2 signaling inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH. Significance: Development of agonists or antagonists of NAADP should provide a novel approach to specifically manipulate autophagy.

Original languageEnglish (US)
Pages (from-to)24247-24263
Number of pages17
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

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