TY - JOUR
T1 - Two-year clinical evaluation of a proanthocyanidins-based primer in non-carious cervical lesions
T2 - A double-blind randomized clinical trial
AU - de Souza, Lidiane Costa
AU - Rodrigues, Nara Sousa
AU - Cunha, Diana Araújo
AU - Feitosa, Victor Pinheiro
AU - Santiago, Sérgio Lima
AU - Reis, Alessandra
AU - Loguercio, Alessandro D.
AU - Perdigão, Jorge
AU - Saboia, Vicente de Paulo Aragão
N1 - Funding Information:
This investigation was supported by research grants from FUNCAP (Grant# CI3-0093-000670100/14 ) and CAPES (scholarship). The authors would like to thank the generous donations of resin composite IPS Empress Direct by Ivoclar Vivadent.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/5
Y1 - 2020/5
N2 - Objectives: This double-blind randomized clinical trial evaluated the influence of pre-treatment with proanthocyanidins (PA) from grape seed extract on the clinical behavior of a simplified etch-and-rinse adhesive placed in non-carious cervical lesions (NCCLs) over 6- and 24-months. Materials and methods: A total of 135 restorations were randomly inserted in 45 subjects. The NCCLs were etched with 37 % phosphoric acid for 15 s and distributed into 3 groups: Control (PA0) - adhesive ExciTE F applied as per the manufacturer's recommendations; PA2 and PA5 groups – 2 wt% and 5 wt% PA solution, respectively, were applied for 60 s and washed for 30 s prior to application of the adhesive. The resin composite was placed incrementally and light-cured. The restorations were evaluated at baseline, 6 months (6 m) and 24 months (24 m) using both the FDI and USPHS criteria. Statistical analyses were carried out using Friedman repeated-measures analysis of variance by rank and the Wilcoxon test (α = 0.05). Results: The retention rates were 98 % (PA0), 98 % (PA2) and 83 % (PA5) after 6 m and 93 % (PA0), 89 % (PA2) and 70 % (PA5) after 24 m. Only PA5 resulted in a significant lower retention rate at 6 m and at 24 m compared with that of baseline (p = 0.03). All groups resulted in a significantly worse marginal adaptation and marginal staining for the FDI criteria when the baseline vs. the 24 m recall data were compared. These differences were considered clinically acceptable under the FDI criteria. Conclusions: The application of PA as a primer did not result in clinical advantages after 24 m of clinical service, regardless of the concentration used. Clinical Relevance: It has been reported that PA, a collagen crosslinking agent, increases the durability of the dentin-resin interface. However, no effects were found clinically after 24 months.
AB - Objectives: This double-blind randomized clinical trial evaluated the influence of pre-treatment with proanthocyanidins (PA) from grape seed extract on the clinical behavior of a simplified etch-and-rinse adhesive placed in non-carious cervical lesions (NCCLs) over 6- and 24-months. Materials and methods: A total of 135 restorations were randomly inserted in 45 subjects. The NCCLs were etched with 37 % phosphoric acid for 15 s and distributed into 3 groups: Control (PA0) - adhesive ExciTE F applied as per the manufacturer's recommendations; PA2 and PA5 groups – 2 wt% and 5 wt% PA solution, respectively, were applied for 60 s and washed for 30 s prior to application of the adhesive. The resin composite was placed incrementally and light-cured. The restorations were evaluated at baseline, 6 months (6 m) and 24 months (24 m) using both the FDI and USPHS criteria. Statistical analyses were carried out using Friedman repeated-measures analysis of variance by rank and the Wilcoxon test (α = 0.05). Results: The retention rates were 98 % (PA0), 98 % (PA2) and 83 % (PA5) after 6 m and 93 % (PA0), 89 % (PA2) and 70 % (PA5) after 24 m. Only PA5 resulted in a significant lower retention rate at 6 m and at 24 m compared with that of baseline (p = 0.03). All groups resulted in a significantly worse marginal adaptation and marginal staining for the FDI criteria when the baseline vs. the 24 m recall data were compared. These differences were considered clinically acceptable under the FDI criteria. Conclusions: The application of PA as a primer did not result in clinical advantages after 24 m of clinical service, regardless of the concentration used. Clinical Relevance: It has been reported that PA, a collagen crosslinking agent, increases the durability of the dentin-resin interface. However, no effects were found clinically after 24 months.
KW - Clinical study
KW - Dentin-bonding agents
KW - Non-carious cervical lesions
KW - Proanthocyanidins
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U2 - 10.1016/j.jdent.2020.103325
DO - 10.1016/j.jdent.2020.103325
M3 - Article
C2 - 32205201
AN - SCOPUS:85082665473
SN - 0300-5712
VL - 96
JO - Journal of Dentistry
JF - Journal of Dentistry
M1 - 103325
ER -