TY - JOUR
T1 - Type 2 diabetes in childhood
T2 - Clinical characteristics and role of β-cell autoimmunity
AU - Badaru, Angela
AU - Pihoker, Catherine
PY - 2012/2/1
Y1 - 2012/2/1
N2 - The global obesity epidemic has led to dramatic increases in the incidence and prevalence of type 2 diabetes mellitus (T2DM) among youth worldwide. In today's clinical practice it has become increasingly difficult to distinguish type 1 diabetes mellitus (T1DM) from T2DM as many children with T1DM are overweight at diagnosis. Numerous recent publications note a significant proportion of physician-diagnosed T2DM youth with evidence of pancreatic autoimmunity, exemplifying the challenges in distinguishing between T1DM and T2DM. The clinical implications of the phenomenon of antibody positivity in phenotypic T2DM youth, also referred to as "type 1.5 diabetes" (T1.5 DM), "double diabetes," "latent autoimmune diabetes in youth" (LADY), and "hybrid diabetes," are unclear at present. Current and future work should determine if the presence of autoantibodies in phenotypic T2DM youth/children affects clinical course; this will facilitate the development of optimal treatment strategies.
AB - The global obesity epidemic has led to dramatic increases in the incidence and prevalence of type 2 diabetes mellitus (T2DM) among youth worldwide. In today's clinical practice it has become increasingly difficult to distinguish type 1 diabetes mellitus (T1DM) from T2DM as many children with T1DM are overweight at diagnosis. Numerous recent publications note a significant proportion of physician-diagnosed T2DM youth with evidence of pancreatic autoimmunity, exemplifying the challenges in distinguishing between T1DM and T2DM. The clinical implications of the phenomenon of antibody positivity in phenotypic T2DM youth, also referred to as "type 1.5 diabetes" (T1.5 DM), "double diabetes," "latent autoimmune diabetes in youth" (LADY), and "hybrid diabetes," are unclear at present. Current and future work should determine if the presence of autoantibodies in phenotypic T2DM youth/children affects clinical course; this will facilitate the development of optimal treatment strategies.
KW - Accelerator hypothesis
KW - Antibody-positive phenotypic T2DM youth
KW - Diabetes autoantibodies
KW - Type 1.5 diabetes
KW - Type 2 diabetes in youth
KW - β-cell autoimmunity
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U2 - 10.1007/s11892-011-0247-2
DO - 10.1007/s11892-011-0247-2
M3 - Article
C2 - 22139556
AN - SCOPUS:84857055158
VL - 12
SP - 75
EP - 81
JO - Current Diabetes Reports
JF - Current Diabetes Reports
SN - 1534-4827
IS - 1
ER -