TY - JOUR
T1 - Tyrosine kinase signalling in breast cancer. Insulin-like growth factors and their receptors in breast cancer
AU - Zhang, X.
AU - Yee, D.
PY - 2000
Y1 - 2000
N2 - The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autophosphorylation, and then binds and phosphorylates additional signaling molecules. These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells. Recent data demonstrate that the IGF receptor system actively interacts with the estrogen receptor and integrin receptor systems. Cross-talk among these pathways regulates breast cancer proliferation, protection from cell death, and metastasis. Better understanding of IGF biochemical signaling pathways is of utmost importance for developing therapies for breast cancer.
AB - The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autophosphorylation, and then binds and phosphorylates additional signaling molecules. These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells. Recent data demonstrate that the IGF receptor system actively interacts with the estrogen receptor and integrin receptor systems. Cross-talk among these pathways regulates breast cancer proliferation, protection from cell death, and metastasis. Better understanding of IGF biochemical signaling pathways is of utmost importance for developing therapies for breast cancer.
KW - Breast cancer
KW - Insulin-like growth factor
KW - Insulin-like growth factor receptor
KW - Signal transduction
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U2 - 10.1186/bcr50
DO - 10.1186/bcr50
M3 - Review article
C2 - 11250706
AN - SCOPUS:0034469081
SN - 1465-5411
VL - 2
SP - 170
EP - 175
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 3
ER -