Abstract
We compared the effect of subcostal transversus abdominis plane (TAP) block with liposomal bupivacaine to TAP block with non-liposomal bupivacaine on postoperative maximal pain scores in patients undergoing donor nephrectomy. Sixty patients were prospectively randomly assigned to receive ultrasound-guided bilateral TAPs with either 1.3% liposomal bupivacaine and normal saline or 0.25% non-liposomal bupivacaine with adrenaline. There was a significant decrease in maximal pain scores in the liposomal bupivacaine TAP group when compared with the non-liposomal bupivacaine group median (IQR [range]), 24–48 h after injection, 5 (3.0–5.2 [0–10]) vs. 6 (4.5–7.0 [1––9]) p = 0.009; 48–72 h after injection, 3 (2.0–5.0 [0–8]) vs. 5 (3.0–7.0 [0–10]) p = 0.02; and in opioid use 48–72 h after injection, mean (SD) μg equivalents of fentanyl 105 (97) vs. 182 (162) p = 0.03. Liposomal bupivacaine via subcostal TAP infiltration provided superior analgesia up to 72 h after injection when compared with non-liposomal bupivacaine.
Original language | English (US) |
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Pages (from-to) | 930-937 |
Number of pages | 8 |
Journal | Anaesthesia |
Volume | 71 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2016 |
Bibliographical note
Publisher Copyright:© 2016 The Association of Anaesthetists of Great Britain and Ireland.
Keywords
- Donor nephrectomy
- Liposomal bupivacaine
- Transversus abdominis plane block