Abstract
A novel single-shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low-concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J-coupled spins from selected coupling partners using a homonuclear Hartmann-Hahn polarization transfer with adiabatic pulses. The current implementation uses 1D-TOCSY with single-voxel localization based on LASER to recover the H1 proton of β-glucose at 4.63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform.
Original language | English (US) |
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Pages (from-to) | 783-789 |
Number of pages | 7 |
Journal | Magnetic resonance in medicine |
Volume | 53 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2005 |
Keywords
- Adiabatic pulses
- Editing
- Glucose
- Lactate
- Spectroscopy
- TOCSY