TY - JOUR
T1 - Uniaxial and biaxial mechanical behavior of human amnion
AU - Oyen, Michelle L.
AU - Stylianopoulos, Triantafyllos
AU - Barocas, Victor H.
AU - Calvin, Steven E.
AU - Cook, Robert F.
PY - 2005
Y1 - 2005
N2 - Chorioamnion, the membrane surrounding a fetus during gestation (the "amniotic sac"), is a structural soft tissue for which the mechanical behavior is poorly understood-despite its critical role in maintaining a successful pregnancy and delivery. Preterm rupture of the chorioamnion accounts for one third of all premature births. The structural component of chorioamnion is the amnion sublayer, which provides the membrane's mechanical integrity via a dense collagen network. Amnion uniaxial and planar equi-biaxial tension testing was performed using monotonie loading, cyclic loading and stress-relaxation. The prefailure material behavior was highly nonlinear, exhibiting an approximately quadratic response. Cyclic testing, both uniaxial and biaxial, exhibited dramatic energy dissipation in the first cycle followed by less hysteresis on subsequent cycles and an eventual stable hysteresis response with approximately 20% energy dissipation per cycle. Stress-relaxation testing, both uniaxial and biaxial, demonstrated a load dependent response and continued relaxation after long hold times. A nonlinear viscoelastic (separable) hereditary integral approach was used to model the amnion stress-strain-time response during relaxation. The mechanical results are discussed within the context of the in vivo clinical performance of amnion, and the potential for membrane repair.
AB - Chorioamnion, the membrane surrounding a fetus during gestation (the "amniotic sac"), is a structural soft tissue for which the mechanical behavior is poorly understood-despite its critical role in maintaining a successful pregnancy and delivery. Preterm rupture of the chorioamnion accounts for one third of all premature births. The structural component of chorioamnion is the amnion sublayer, which provides the membrane's mechanical integrity via a dense collagen network. Amnion uniaxial and planar equi-biaxial tension testing was performed using monotonie loading, cyclic loading and stress-relaxation. The prefailure material behavior was highly nonlinear, exhibiting an approximately quadratic response. Cyclic testing, both uniaxial and biaxial, exhibited dramatic energy dissipation in the first cycle followed by less hysteresis on subsequent cycles and an eventual stable hysteresis response with approximately 20% energy dissipation per cycle. Stress-relaxation testing, both uniaxial and biaxial, demonstrated a load dependent response and continued relaxation after long hold times. A nonlinear viscoelastic (separable) hereditary integral approach was used to model the amnion stress-strain-time response during relaxation. The mechanical results are discussed within the context of the in vivo clinical performance of amnion, and the potential for membrane repair.
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M3 - Conference article
AN - SCOPUS:20344367767
SN - 0272-9172
VL - 844
SP - 161
EP - 166
JO - Materials Research Society Symposium Proceedings
JF - Materials Research Society Symposium Proceedings
M1 - Y5.3
T2 - Mechanical Properties of Bioinspired and Biological Materials
Y2 - 29 November 2004 through 2 December 2004
ER -