TY - JOUR
T1 - Unrelated donor allogeneic transplantation for adult acute lymphoblastic leukemia
T2 - A review
AU - Bachanova, V.
AU - Weisdorf, D.
PY - 2008/3
Y1 - 2008/3
N2 - Acute lymphoblastic leukemia is highly sensitive to induction chemotherapy; however, long-term survival in adults has been less than 35%, primarily as a result of high relapse rate. Treatment for relapsed disease is even less successful. The optimal post-remission therapy in the first complete remission offers the best opportunity for leukemia-free survival. Allogeneic donor stem cell transplantation can offer a unique anti-leukemia effect and a potential for extended survival. We will discuss advances in unrelated donor (URD) stem cells transplantation, improvements in transplantation process and supportive care along with growing experience with umbilical cord blood (UCB) allografts.
AB - Acute lymphoblastic leukemia is highly sensitive to induction chemotherapy; however, long-term survival in adults has been less than 35%, primarily as a result of high relapse rate. Treatment for relapsed disease is even less successful. The optimal post-remission therapy in the first complete remission offers the best opportunity for leukemia-free survival. Allogeneic donor stem cell transplantation can offer a unique anti-leukemia effect and a potential for extended survival. We will discuss advances in unrelated donor (URD) stem cells transplantation, improvements in transplantation process and supportive care along with growing experience with umbilical cord blood (UCB) allografts.
UR - http://www.scopus.com/inward/record.url?scp=40749102912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40749102912&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1705889
DO - 10.1038/sj.bmt.1705889
M3 - Review article
C2 - 17968329
AN - SCOPUS:40749102912
SN - 0268-3369
VL - 41
SP - 455
EP - 464
JO - Bone marrow transplantation
JF - Bone marrow transplantation
IS - 5
ER -
