Unusual multiple production of N-acylhomoserine lactones a by Burkholderia sp. strain C10B isolated from dentine caries

Share Yuan Goh, Wen Si Tan, Saad Ahmed Khan, Hooi Pin Chew, Noor Hayaty Abu Kasim, Wai Fong Yin, Kok Gan Chan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Bacteria realize the ability to communicate by production of quorum sensing (QS) molecules called autoinducers, which regulate the physiological activities in their ecological niches. The oral cavity could be a potential area for the presence of QS bacteria. In this study, we report the isolation of a QS bacterial isolate C10B from dentine caries. Preliminary screening using Chromobacterium violaceum CV026 biosensor showed that isolate C10B was able to produce N-acylhomoserine lactones (AHLs). This bacterium was further identified as a member of Burkholderia, an opportunistic pathogen. The isolated Burkholderia sp. was confirmed to produce N-hexanoyl-L-homoserine lactone (C6-HSL), N-octanoyl-L-homoserine lactone (C8-HSL), N-decanoyl-L-homoserine lactone (C10-HSL) and N-dodecanoyl-L-homoserine lactone (C12-HSL).

Original languageEnglish (US)
Pages (from-to)8940-8949
Number of pages10
JournalSensors (Switzerland)
Volume14
Issue number5
DOIs
StatePublished - May 21 2014
Externally publishedYes

Keywords

  • Chromobacterium violaceum CV026
  • Dentine caries
  • N-decanoyl-L-homoserine lactone (C10-HSL)
  • N-dodecanoyl-L-homoserine lactone (C12-HSL)
  • N-hexanoyl-L-homoserine lactone (C6-HSL)
  • N-octanoyl-L-homoserine lactone (C8-HSL)
  • Oral cavity
  • Quorum sensing (QS)

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