Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells

Zhongcai Ma; Bong Sook Jhun; Chad K. Oh

doi:10.1016/j.febslet.2007.08.034

Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells

Zhongcai Ma, Bong Sook Jhun, Chad K. Oh

Research output: Contribution to journal › Article › peer-review

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Abstract

Plasminogen activator inhibitor (PAI)-1 promotes development of asthma. PAI-1 mRNA and protein are markedly induced in activated mast cells (MCs), a major effector cell type in asthma. However, regulatory mechanisms of PAI-1 transcription in MCs are unknown. We present first evidence that PAI-1 is transcriptionally regulated in human MCs (hMCs). In addition to three enhancer regions, we demonstrated that the E-box at -566 bp to -561 bp is the negative regulatory element, and the specific and constitutive binding of the upstream stimulating factor-1 to this E-box is the key mechanism of the negative regulation of PAI-1 expression in hMCs.

Original language	English (US)
Pages (from-to)	4485-4490
Number of pages	6
Journal	FEBS Letters
Volume	581
Issue number	23
DOIs	https://doi.org/10.1016/j.febslet.2007.08.034
State	Published - Sep 18 2007
Externally published	Yes

Keywords

E-box
Human mast cells (hMCs)
Plasminogen activator inhibitor-1 (PAI-1)
Transcription
Upstream stimulating factor-1 (USF-1)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Plasminogen activator inhibitor (PAI)-1 promotes development of asthma. PAI-1 mRNA and protein are markedly induced in activated mast cells (MCs), a major effector cell type in asthma. However, regulatory mechanisms of PAI-1 transcription in MCs are unknown. We present first evidence that PAI-1 is transcriptionally regulated in human MCs (hMCs). In addition to three enhancer regions, we demonstrated that the E-box at -566 bp to -561 bp is the negative regulatory element, and the specific and constitutive binding of the upstream stimulating factor-1 to this E-box is the key mechanism of the negative regulation of PAI-1 expression in hMCs.",

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AU - Oh, Chad K.

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KW - Transcription

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Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells

Abstract

Keywords

UN SDGs

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