Abstract
In the present study, urea, a well-known adductor for linear compounds was successfully utilized for inclusion of glipizide-a highly substituted cyclic organic compound through a modified technique. Formation of glipizide co-inclusion compounds in urea was confirmed by FTIR, DSC and XRD. The minimum proportion of rapidly adductible endocyte (RAE) required for adduction of glipizide in urea was estimated by a modified Zimmerschied calorimetric method. Urea-GLP-RAE inclusion compounds containing varying proportions of guests were prepared and their thermal behaviour studied by DSC. The co-inclusion compounds were found to exhibit good content uniformity. Through the formation of co-inclusion compounds of urea, it was possible to achieve steep improvement in the dissolution efficiency of glipizide, which is a BCS class II drug.
Original language | English (US) |
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Pages (from-to) | 203-209 |
Number of pages | 7 |
Journal | Journal of Inclusion Phenomena and Macrocyclic Chemistry |
Volume | 60 |
Issue number | 3-4 |
DOIs | |
State | Published - Apr 1 2008 |
Keywords
- Adduction
- Complexation
- Content uniformity
- Dissolution rate
- Glipizide
- Urea inclusion compounds