Urine C-peptide, β-Cell Function, and Insulin Requirement

Elizabeth B. Rappaport, Robert A. Ulstrom, Donnell D. Etzwiler, Daniel Fife, Bo E. Hedlund, Michael W Steffes

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6 Scopus citations


Urinary C-peptide excretion was investigated as a method for monitoring β-cell function in diabetic patients and for studying the contribution of endogenous insulin production to diabetic control. Control subjects had variations in serum and urine C-peptide immunoreactivity that correlated with basal and meal-related insulin secretion. In a group of well-controlled juvenile diabetic patients, those receiving high doses of insulin had low or negligible C-peptide excretion, whereas most patients with low exogenous insulin requirements had near-normal urinary C-peptide excretion. Patients treated for diabetic ketoacidosis had recovery of β-cell function as measured by C-peptide immunoreactivity in serial urine specimens. Thus, measurement of urinary C-peptide excretion is a simple technique that may be useful in assessing endogenous insulin production in juvenile diabetic patients. (Am J Dis Child 134:1129-1133, 1980.

Original languageEnglish (US)
Pages (from-to)1129-1133
Number of pages5
JournalAmerican Journal of Diseases of Children
Issue number12
StatePublished - Dec 1980


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