TY - JOUR
T1 - Urine C-peptide, β-Cell Function, and Insulin Requirement
AU - Rappaport, Elizabeth B.
AU - Ulstrom, Robert A.
AU - Etzwiler, Donnell D.
AU - Fife, Daniel
AU - Hedlund, Bo E.
AU - Steffes, Michael W
PY - 1980/12
Y1 - 1980/12
N2 - Urinary C-peptide excretion was investigated as a method for monitoring β-cell function in diabetic patients and for studying the contribution of endogenous insulin production to diabetic control. Control subjects had variations in serum and urine C-peptide immunoreactivity that correlated with basal and meal-related insulin secretion. In a group of well-controlled juvenile diabetic patients, those receiving high doses of insulin had low or negligible C-peptide excretion, whereas most patients with low exogenous insulin requirements had near-normal urinary C-peptide excretion. Patients treated for diabetic ketoacidosis had recovery of β-cell function as measured by C-peptide immunoreactivity in serial urine specimens. Thus, measurement of urinary C-peptide excretion is a simple technique that may be useful in assessing endogenous insulin production in juvenile diabetic patients. (Am J Dis Child 134:1129-1133, 1980.
AB - Urinary C-peptide excretion was investigated as a method for monitoring β-cell function in diabetic patients and for studying the contribution of endogenous insulin production to diabetic control. Control subjects had variations in serum and urine C-peptide immunoreactivity that correlated with basal and meal-related insulin secretion. In a group of well-controlled juvenile diabetic patients, those receiving high doses of insulin had low or negligible C-peptide excretion, whereas most patients with low exogenous insulin requirements had near-normal urinary C-peptide excretion. Patients treated for diabetic ketoacidosis had recovery of β-cell function as measured by C-peptide immunoreactivity in serial urine specimens. Thus, measurement of urinary C-peptide excretion is a simple technique that may be useful in assessing endogenous insulin production in juvenile diabetic patients. (Am J Dis Child 134:1129-1133, 1980.
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U2 - 10.1001/archpedi.1980.02130240013006
DO - 10.1001/archpedi.1980.02130240013006
M3 - Article
C2 - 7004175
AN - SCOPUS:0019197565
SN - 0096-8994
VL - 134
SP - 1129
EP - 1133
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 12
ER -