Use of an Ultrasound Blood-Mimicking Fluid for Doppler Investigations of Turbulence In Vitro

Meghan L. Thorne; Tamie L. Poepping; Richard N. Rankin; David A. Steinman; David W. Holdsworth

doi:10.1016/j.ultrasmedbio.2007.12.014

Use of an Ultrasound Blood-Mimicking Fluid for Doppler Investigations of Turbulence In Vitro

Meghan L. Thorne, Tamie L. Poepping, Richard N. Rankin, David A. Steinman, David W. Holdsworth

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Turbulence is an important factor in the assessment of stenotic disease and a possible causative mechanism for thromboembolism. Previous Doppler studies of turbulence have typically used whole-blood preparations or suspensions of erythrocytes. Recently, a water-glycerol based blood-mimicking fluid (BMF) has been developed for use in Doppler ultrasound studies. This fluid has desirable ultrasound properties but it has not previously been described during in vitro investigations of turbulence intensity. We report on investigations of grid-generated and constrained-jet turbulence in an in vitro test system. The BMF was found to generate significant levels of turbulence during steady flow at physiological flow rates, producing turbulent patterns in the distal region that were consistent with previous studies. Turbulence intensity increased significantly with flow rate (p < 0.005) for both the constrained jet and the constrained grid. Based on our observations, we conclude that a water-glycerol based BMF provides a suitable working fluid during in vitro investigations of turbulence using Doppler ultrasound. (E-mail: david.holdsworth@imaging.robarts.ca).

Original language	English (US)
Pages (from-to)	1163-1173
Number of pages	11
Journal	Ultrasound in Medicine and Biology
Volume	34
Issue number	7
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2007.12.014
State	Published - Jul 2008
Externally published	Yes

Bibliographical note

Funding Information:
The authors acknowledge ATL (Advanced Technology Laboratories, Philips, Seattle, WA, USA) for the UM8 ultrasound unit. Financial support has been provided by the Heart and Stroke Foundation of Ontario (grant no. T-5135). Vessel models were fabricated with support from the Canadian Institutes for Health Research (group grant no. GR-14973). Drs. Holdsworth and Steinman are Career Investigators, supported by the Heart and Stroke Foundation of Ontario.

Keywords

Backscattered power
Blood flow velocity
Blood-mimicking fluid
Doppler ultrasound
Grid
In vitro modeling
Orifice
Turbulence intensity

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title = "Use of an Ultrasound Blood-Mimicking Fluid for Doppler Investigations of Turbulence In Vitro",

abstract = "Turbulence is an important factor in the assessment of stenotic disease and a possible causative mechanism for thromboembolism. Previous Doppler studies of turbulence have typically used whole-blood preparations or suspensions of erythrocytes. Recently, a water-glycerol based blood-mimicking fluid (BMF) has been developed for use in Doppler ultrasound studies. This fluid has desirable ultrasound properties but it has not previously been described during in vitro investigations of turbulence intensity. We report on investigations of grid-generated and constrained-jet turbulence in an in vitro test system. The BMF was found to generate significant levels of turbulence during steady flow at physiological flow rates, producing turbulent patterns in the distal region that were consistent with previous studies. Turbulence intensity increased significantly with flow rate (p < 0.005) for both the constrained jet and the constrained grid. Based on our observations, we conclude that a water-glycerol based BMF provides a suitable working fluid during in vitro investigations of turbulence using Doppler ultrasound. (E-mail: david.holdsworth@imaging.robarts.ca).",

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Use of an Ultrasound Blood-Mimicking Fluid for Doppler Investigations of Turbulence In Vitro

Abstract

Bibliographical note

Keywords

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