TY - JOUR
T1 - Use of androgen deprivation therapy in prostate cancer
T2 - Indications and prevalence
AU - Connolly, Roisin M.
AU - Carducci, Michael A.
AU - Antonarakis, Emmanuel S.
PY - 2012/3
Y1 - 2012/3
N2 - Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer. This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.
AB - Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer. This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.
KW - androgen deprivation therapy
KW - androgen synthesis
KW - anti-androgen
KW - prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84858045491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858045491&partnerID=8YFLogxK
U2 - 10.1038/aja.2011.103
DO - 10.1038/aja.2011.103
M3 - Review article
C2 - 22231299
AN - SCOPUS:84858045491
SN - 1008-682X
VL - 14
SP - 177
EP - 186
JO - Asian Journal of Andrology
JF - Asian Journal of Andrology
IS - 2
ER -