Magnetic hyperthermia for treatment of tumors would benefit greatly from increased heating of the magnetic particles relative to the incident electromagnetic wave power. Micromagnetic simulations including thermal fluctuations show that the use of an incident square wave, as opposed to the usual sine wave, increases the normalized heat by at least 50%, with the possibility of much greater improvement for the usual case of particle ensembles that have a distribution of magnetic anisotropies, volumes, and angles to the incident radiation. It is shown that even replacement of the square wave by a limited number of harmonics is highly beneficial.
Bibliographical noteFunding Information:
One of the authors (R.H.V.) thanks Jian-Ping Wang for useful discussion and Hweerin Sohn for checking several key results. This work was supported by National Science Foundation Contract No. BME 0730825.
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