Use of urine-based markers for detection and monitoring of bladder cancer

G. Pirtskalaishvili, R. H. Getzenberg, B. R. Konety

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Diagnosis and monitoring of bladder cancer present a difficult clinical problem. Urine cytology with confirmatory cystoscopy form the cornerstone of diagnosis at the present time. The subjectivity and low sensitivity of cytology led to the development of numerous tests as adjuncts to cystoscopy for the diagnosis and follow-up of bladder cancer patients. These tests usually are objective, quantitative (NMP-22, BTA TRAK, BLCA-4, telomerase activity, etc.), or qualitative (BTA Stat and FDP) and have higher sensitivity than cytology, but some have lower specificity. We review the different, new urine-based tests that were developed recently for the diagnosis and monitoring of patients with bladder cancer. The advantages and disadvantages of these tests are discussed, as well as their possible future role in the management of patients with bladder cancer.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalTechniques in Urology
Volume5
Issue number4
StatePublished - Dec 16 1999

Keywords

  • Bladder cancer
  • Diagnosis
  • Urine markers

Fingerprint

Dive into the research topics of 'Use of urine-based markers for detection and monitoring of bladder cancer'. Together they form a unique fingerprint.

Cite this